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Table 2 Results of laboratory tests in the hereby reported patients

From: Activated phosphoinositide 3-kinase delta syndrome 1 and 2 (APDS 1 and APDS 2): similarities and differences based on clinical presentation in two boys

Laboratory parameter

Case 1b

Age-specific norma

Case 2c

Age-specific norma

Leukocyte count

5.14 K/µl

5–15 K/µl

6.48 K/µl

5–13 K/µl

Neutrophil count

3.23 K/µl

1.5–8 K/µl

3.04 K/µl

2–8 K/µl

Hemoglobin concentration

8.8 g/dl ↓↓

11.5–14.0 g/dl

13.0 g/dl

11.5–15.5 g/dl

Platelet count

145 K/µl

100–490 K/µl

373 K/µl

100–450 K/µl

IgG concentration

<1.56 g/l ↓↓↓

4.28–12.3 g/l

2.0 g/l ↓↓↓

8.5–13.0 g/l

IgA concentration

0.33 g/l ↓↓

1.08–2.43 g/l

<0.06 g/l ↓↓↓

0.91–2.55 g/l

IgM concentration

2.3 g/l

0.3–1.12 g/l

0.27 g/l ↓↓↓

0.66–1.55 g/l

B lymphocytes (CD 19+)

63/µl (4.72%) ↓↓↓

400–1700/µl

164/µl (5.4%) ↓↓

200–600/µl

T lymphocytes (CD 3+)

1515/µl (78.9%) ↓↓

2120–2830/µl

2202/µl (72.5%)

800–3500/µl

T-helper lymphocytes (CD3+CD4+)

207/µl (15.32%) ↓↓

640–1560/µl

777/µl (25.5%)

400–2100/µl

T-helper memory lymphocytes (CD3+CD4+CD45RO+)

13.88% (186/µl)

8.7–25.9%

4.5% (137/µl) ↓↓↓

27.2–62.0%

Naïve T-helper lymphocytes (CD3+CD4+CD45RA+)

2.35% (31/µl) ↓↓↓

13.3–37.8%

61.1% (1861/µl)

31.1–66.3%

T-cytotoxic lymphocytes (CD3+CD8+)

680/µl (50.47%) ↑

200–630/µl

1075/µl (35.3%)

200–1200/µl

T-cytotoxic memory lymphocytes (CD3+CD8+CD45RO+)

46.18% (622/µl) ↑↑

3.9–20.2%

54.8% (1669/µl) ↑↑

15.9–46.4%

Naïve T-cytotoxic lymphocytes (CD3+CD8+CD45RA+)

24.9% (336/µl) ↑

6.9–22%

16.6% (506/µl) ↓↓

44.1–77.1%

  1. aDifferences in normal ranges reflect different age of patients at the time of laboratory testing
  2. bLaboratory test was performed on the patient aged 3 years
  3. cLaboratory test was performed on the patient aged 10 years