Local eosinophils are associated with increased IgA subclass levels in the sinonasal mucosa of chronic rhinosinusitis with polyp patients

Table 4 Immunohistochemistry results of control, CRSsNP and CRSwNP groups

	Control	CRSsNP	CRSwNP	Control vs. CRSsNP	Control vs. CRSwNP	CRSwNP vs. CRSsNP
Total IgA LP	3 (2–4)	6.5 (5–8.5)	8 (5–13.5)	< 0.001	< 0.001	0.77
IgA2 LP	0 (0–0)	1 (1–1)	1 (0–2)	0.023	< 0.001	0.721
IgA1 LP	2.5 (2–3)	6.5 (5–8.5)	6.5 (4–10)	<0.001	<0.001	0.82
Total IgA EP	1 (1–1)	1 (0.5–2)	2 (1–3)	0.34	0.002	0.122
IgA2 EP	0 (0–0)	0 (0–0.5)	0 (0–1)	0.1	0.11	0.1
IgA1 EP	1 (1–1)	1 (0.5–2)	2 (1–2)	0.34	0.001	0.11
CD20	1 (1–2)	5.5 (3–8)	14 (6.5–34.5)	0.001	< 0.001	0.134
CD138	4 (2–5)	5 (2–7)	10.5 (5–33.5)	0.327	< 0.001	0.009

Values are expressed as medians (IQR). Mann-Whitney U test was used for unpaired comparisons
CRSsNP Chronic rhinosinusitis without nasal polyps, CRSwNP Chronic rhinosinusitis with nasal polyps, LP Lamina propria, EP Epithelium
P < 0.05 was considered statistically significant. Italic P values show significant results (<0.05)

ISSN: 1710-1492