Local eosinophils are associated with increased IgA subclass levels in the sinonasal mucosa of chronic rhinosinusitis with polyp patients

Table 6 Immunohistochemistry results in Eosinophilic and Non-eosinophilic CRSwNP subgroups

	ENP	N-ENP	ENP vs. N-ENP	ENP vs. CRSsNP	N-ENP vs. CRSsNP
Total IgA LP	11 (8.5–15)	5 (3–6)	< 0.001	0.002	0.007
IgA2 LP	2 (1–3)	0 (0–1)	0.003	0.053	0.11
IgA1 LP	10 (7–12.5)	4 (3–5)	< 0.001	0.023	0.002
Total IgA EP	3 (1.5–3)	1 (1–2)	0.013	0.037	0.99
IgA2 EP	1 (0–1)	0 (0–0)	0.015	0.123	0.47
IgA1 EP	2 (1–2)	1 (1–2)	0.179	0.85	0.611
B cells (CD20)	21 (8–44)	9 (7–16)	0.051	0.026	0.225
Plasma cells (CD138)	25 (7–42)	6 (4–14)	0.022	0.01	0.205

Values are expressed as median (IQR). Mann-Whitney U test was used for unpaired comparisons
CRSsNP Chronic rhinosinusitis without nasal polyps, ENP Eosinophilic chronic rhinosinusitis with nasal polyps, N-ENP Non-eosinophilic chronic rhinosinusitis with nasal polyps, LP Lamina propria, EP Epithelium
P < 0.05 was considered statistically significant. Italics P values show significant results (<0.05)

ISSN: 1710-1492