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Table 6 Immunohistochemistry results in Eosinophilic and Non-eosinophilic CRSwNP subgroups

From: Local eosinophils are associated with increased IgA subclass levels in the sinonasal mucosa of chronic rhinosinusitis with polyp patients

 ENPN-ENPENP vs. N-ENPENP vs. CRSsNPN-ENP vs. CRSsNP
Total IgA LP11 (8.5–15)5 (3–6)< 0.0010.0020.007
IgA2 LP2 (1–3)0 (0–1)0.0030.0530.11
IgA1 LP10 (7–12.5)4 (3–5)< 0.0010.0230.002
Total IgA EP3 (1.5–3)1 (1–2)0.0130.0370.99
IgA2 EP1 (0–1)0 (0–0)0.0150.1230.47
IgA1 EP2 (1–2)1 (1–2)0.1790.850.611
B cells (CD20)21 (8–44)9 (7–16)0.0510.0260.225
Plasma cells (CD138)25 (7–42)6 (4–14)0.0220.010.205
  1. Values are expressed as median (IQR). Mann-Whitney U test was used for unpaired comparisons
  2. CRSsNP Chronic rhinosinusitis without nasal polyps, ENP Eosinophilic chronic rhinosinusitis with nasal polyps, N-ENP Non-eosinophilic chronic rhinosinusitis with nasal polyps, LP Lamina propria, EP Epithelium
  3. P < 0.05 was considered statistically significant. Italics P values show significant results (<0.05)