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Table 4 Comparative analyses of single ANCA test vs. combinational tests for ANCA/ASCA in the diagnosis of UC

From: Assessment of clinical activity and severity using serum ANCA and ASCA antibodies in patients with ulcerative colitis

Antibody/diseaseSensitivity (%)Specificity (%)Positive predictive value (%)Negative predictive value (%)
ANCA+/UC61.9091.4583.3377.65
ANCA+/ASCA/UC55.2494.0886.5775.26
ASCA+/disease control group5.7783.908.3377.83
ASCA+/ANCA/disease control group3.8588.788.0078.45
  1. More than one positive test of ASCA-IgG and ASCA-IgA subtypes was regarded positive; two negative tests of the subtypes were regarded negative