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Table 4 Comparative analyses of single ANCA test vs. combinational tests for ANCA/ASCA in the diagnosis of UC

From: Assessment of clinical activity and severity using serum ANCA and ASCA antibodies in patients with ulcerative colitis

Antibody/disease

Sensitivity (%)

Specificity (%)

Positive predictive value (%)

Negative predictive value (%)

ANCA+/UC

61.90

91.45

83.33

77.65

ANCA+/ASCA/UC

55.24

94.08

86.57

75.26

ASCA+/disease control group

5.77

83.90

8.33

77.83

ASCA+/ANCA/disease control group

3.85

88.78

8.00

78.45

  1. More than one positive test of ASCA-IgG and ASCA-IgA subtypes was regarded positive; two negative tests of the subtypes were regarded negative