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Table 1 Summary of main effects of quercetin on allergic diseases (in vitro studies)

From: Quercetin with the potential effect on allergic diseases

Diseases Dosage Cell/cell line Animal Quercetin’s effect References
Allergic asthma 10−6–3 × 10−4 M Tracheal tissue Male Wistar rat Inhibits rat tracheal contractility [24]
40 µM NCI-H292 cells n/a Inhibit MUC5AC gene expression [25]
40 µM HBE16 n/a Inhibit HNE-induced MUC5AC expression in human airway epithelial cells through PKC/EGFR/ERK signal transduction pathway [26]
Allergic rhinitis 4.0 μM HNEpC n/a Suppressed the ability of cells to produce RANTES and eotaxin [38]
1.0 nM HNEpC   Modified the clinical condition of AR through the suppression of NO production from nasal epithelial cells after IL-4 stimulation [41]
Atopic dermatitis 30 μM RBL-2H3 Wistar rat and BALB/c Upregulation of HO after short exposure
Induction of HO-1 expression after long exposure
[51]
5 mg/ml Keratinocyte n/a Strong ability to scavenge free radicals and protect human keratinocytes against hydrogen peroxide damage [52]
  1. MUC5AC mucin 5 AC, HNE human neutrophil elastase, PKC protein kinase C, EGFR epidermal growth factor receptor, ERK extracellular-regulated kinase, RANTES regulated on activation, normal T cell expressed and secreted, NO nitric oxide, RA allergic rhinitis, HO heme oxygenase, HNEpC human nasal epithelial cells