Quercetin with the potential effect on allergic diseases

Table 1 Summary of main effects of quercetin on allergic diseases (in vitro studies)

Diseases	Dosage	Cell/cell line	Animal	Quercetin’s effect	References
Allergic asthma	10⁻⁶–3 × 10⁻⁴ M	Tracheal tissue	Male Wistar rat	Inhibits rat tracheal contractility	[24]
	40 µM	NCI-H292 cells	n/a	Inhibit MUC5AC gene expression	[25]
	40 µM	HBE16	n/a	Inhibit HNE-induced MUC5AC expression in human airway epithelial cells through PKC/EGFR/ERK signal transduction pathway	[26]
Allergic rhinitis	4.0 μM	HNEpC	n/a	Suppressed the ability of cells to produce RANTES and eotaxin	[38]
Allergic rhinitis	1.0 nM	HNEpC		Modified the clinical condition of AR through the suppression of NO production from nasal epithelial cells after IL-4 stimulation	[41]
Atopic dermatitis	30 μM	RBL-2H3	Wistar rat and BALB/c	Upregulation of HO after short exposure Induction of HO-1 expression after long exposure	[51]
Atopic dermatitis	5 mg/ml	Keratinocyte	n/a	Strong ability to scavenge free radicals and protect human keratinocytes against hydrogen peroxide damage	[52]

MUC5AC mucin 5 AC, HNE human neutrophil elastase, PKC protein kinase C, EGFR epidermal growth factor receptor, ERK extracellular-regulated kinase, RANTES regulated on activation, normal T cell expressed and secreted, NO nitric oxide, RA allergic rhinitis, HO heme oxygenase, HNEpC human nasal epithelial cells

ISSN: 1710-1492