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Fig. 4 | Allergy, Asthma & Clinical Immunology

Fig. 4

From: Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps

Fig. 4

Effect of inhibitors of TMEM16A and PI3K on EGF-induced TMEM16A expression in HNECs from CRSwNP. Cells were treated with EGF (100 ng/ml) alone or with EGF following pretreatment for 30 min with T16Ainh-A01 (10 μM; the specific inhibitor of TMEM16A) or with LY294002 (25 μM; the PI3K inhibitor). a After 4 h total RNA was analyzed by real-time RT-PCR for TMEM16A mRNA expression (n = 6); and b after 24 h the TMEM16A protein in lysates was detected by Western blotting (n = 6). *P < 0.05, between two groups

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