Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

Table 3 Significant associations between SNVs in VDR, CYP2R1, CYP24A1, vitamin D status and 25(OH)D serum levels

Phenotype	SNVs	Alele	Model	OR^a	CI 95%	P value
25(OH)D serum levels
		Alele	Model	B^c	CI 95%	P value
CYP2R1
	rs12794714	A	ADD	− 1.38	− 2.40 to 0.35	0.009
	rs10500804	G	ADD	− 1.37	− 2.40 to 0.35	0.009
CYP24A1
	rs3886163	T	ADD	− 1.48	− 2.77 to 0.18	0.026
Vitamin D defficiency
VDR
	rs59128934	G	ADD	1.78	1.12 to 2.83	0.014
CYP24A1
	rs3886163	T	ADD	1.44	1.05 to 1.99	0.025
Vitamin D insufficiency
VDR
	rs7967152	A	ADD	0.77	0.62 to 0.95	0.013
	rs9729	C	ADD	0.78	0.70 to 0.96	0.017
	rs739837	G	ADD	0.78	0.63 to 0.96	0.019
	rs11168287	G	ADD	0.78	0.63 to 0.97	0.028
	rs7963776	G	ADD	0.79	0.64 to 0.98	0.029
	rs4237855	G	ADD	0.79	0.63 to 0.99	0.038
	rs59128934	G	ADD	2.07	1.28 to 3.34	0.002
	rs7965274	T	ADD	1.31	1.01 to 1.70	0.044
	rs2853564	C	ADD	1.30	1.00 to 1.70	0.049
CYP2R1
	rs12794714	A	ADD	1.41	1.11 to 1.79	0.005
	rs10500804	G	ADD	1.40	1.11 to 1.77	0.006
CYP24A1
	rs4809960	C	ADD	0.69	0.53 to 0.91	0.008
	rs2245153	C	ADD	0.79	0.63 to 0.99	0.042
	rs56229249	G	ADD	1.42	1.04 to 1.94	0.028
	rs34043203	A	ADD	1.49	1.00 to 2.22	0.049

ADD additive analysis model
^aUsing logistic regression adjusted by sex, age and individual genetic ancestry
^bPermutational analysis
^cLinear regression B coefficient adjusted by sex, age, helminth infection and individual genetic ancestry

ISSN: 1710-1492