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Table 4 Summary of studies detecting IgG autoantibody to FcεR1α in subjects with CSU

From: Presence of positive skin prick tests to inhalant allergens and markers of T2 inflammation in subjects with chronic spontaneous urticaria (CSU): a systematic literature review

Reference (author, year)

Region

Definition of CSU in weeks

Number of CSU patients undergoing testing

Number of healthy controls undergoing testing

% prevalence of IgG autoantibody to FcεR1α in study group

Functional assay (F) or non-functional assay (N)

% prevalence of IgG autoantibody to FcεR1α in control group

Number of antihistamine (AH) and/or systemic corticosteroid (SC)-free days

Hide, 1993 [88]

England

> 8

26  + ASST

10

46.1

F

0

2 (AH)

Fiebiger, 1995 [11]

Austria

> 8

32

15

37

N

0

Not stated

Zweiman, 1996 [89]

United States

–

70

20

30

F

15

Not stated

Ferrer 1998 [10]

United States

> 12

53

24

64

N

0

2 (AH)

Fiebiger, 1998 [90]

Austria

> 8

281

41

38

N

–

Not stated

Zuberbier, 2000 [91]

Austria

> 6

48

5

35

N

0

Not stated

Sabroe, 2002 [92]

England

> 6

78

39

26

15

F

N

0

3 (AH), 28 (SC)

Hidvegi, 2003 [93]

Hungary

> 6

50

9

34

N

0

3 (AH), 28 (SC)

Eckman, 2008 [94]

United States

> 6

73

23

59

N

57

Not stated

Lee, 2014 [95]

Taiwan

> 6

40 (20 + ASST) (20 − ASST)

20

47.5 (70) (25)

N

5

Not stated

Ulambayar, 2017 [96]

Taiwan

> 6

125 (64 + ASST) (61 − ASST)

64

24.8 (32.8) (16.4)

N

3.1

5 (AH)

Baioumy, 2018 [97]

Egypt

> 8

40 (18 + ASST) (22 − ASST)

40

52.5 (83.3) (27.3)

N

2.5

5 (AH)

Schoepke, 2019 [98]

Multinational

> 6

182 (107 + ASST)

0

58

N

–

3 (AH), 28 (SC)

Asero, 2020 [99]

Italy

> 6

20

20

50

N

–

Not stated

  1. AH antihistamine, SC systemic corticosteroids