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Table 3 Lymphocyte subpopulation of three STAT3 deficiency patient

From: The clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations

  P4 (%) P8(%) P9 (%)
Cytotoxic T cell (CD8, CD45+CD3+CD8+)
 Central memory cytotoxic T cells (CD8 CM, CD3+CD8+CD45RA−CD27+) 10.40 (6.66–34.14) 19.20 (4.82–24.11) 9.00 (12.08–30.54)
 Naive differentiated cytotoxic T cells (CD8 Naive, CD3+CD8+CD45RA+CD27+) 67.30 (38.19–86.18) 50.50 (47.36–92.45) 36.20 (41.58–77.90)
 Effector memory cytotoxic T cells (CD8 EM, CD3+CD8+CD45RA−CD27−) 5.90 (0.60–12.01) 17.9↑ (0.20–8.94) 6.20 (1.58–13.18)
 Terminally differentiated effector memory cytotoxic T cells (CD8 TEMRA, CD3+CD8+CD45RA+CD27−) 16.40 (0.50–24.45) 12.40 (0.15–28.32) 48.6↑ (1.70–24.62)
CD4 T cell (CD45+CD3+CD4+)
 Central memory helper T cells (CD4 CM, CD3+CD4+CD45RA−CD27+) 21.80 (17.12–47.60) 32.20 (10.15–33.38) 19.50 (22.06–46.46)
 Naive differentiated helper T cells (CD4 Naive, CD3+CD4+CD45RA+CD27+) 75.80 (46.42–81.20) 65.40 (59.28–88.09) 76.30 (45.56–75.28)
 Effector memory helper T cells (CD4 EM, CD3+CD4+CD45RA−CD27−) 2.30 (0.90–5.17) 2.00 (0.42–3.96) 4.10 (2.08–8.78)
 Terminally differentiated effector memory helper T cells (CD4 TEMRA, CD3+CD4+CD45RA+CD27−) 0.00 (0.00–0.50) 0.40 (0.00–1.49) 0.10 (0.00–1.06)
 γδ T cells (γδ T, CD3+TCRγδ+) 0↓ (5.07–17.60) 4.80 (3.95–10.40) 21 (6.92–19.84)
 TCRαβ+ double-negative T (DNT) cells (CD3+TCRαβ+CD4−CD8−) 3.3↑ (0.56–2.36) 5.6↑ (0.41–1.55) 21.2↑ (0.18–2.81)
B cells (CD45+CD19+)
 Memory B (CD19+CD27+IgD−) 2.50↓ (3.60–18.55) 0.40↓ (1.77–7.06) 3.80↓ (7.76–19.90)
 Naïve B (CD19+CD27–IgD+) 91.60↑ (59.59–85.28) 96.70↑ (75.28–92.77) 63.80 (48.36–75.84)
 Transitional B (CD19+CD24++CD38++) 3.80 (4.73–15.68) 29.90↑ (6.04–21.62) 5.30 (2.58–12.30)
 Plasmablasts (CD19+CD24−CD38++) 2.40 (0.60–10.31) 0.90 (0.71–5.88) 3.90 (0.90–7.36)
  1. The number in round bracket presents the age specific reference values according to Reference Values for Peripheral Blood Lymphocyte Subsets of Healthy Children in China