Table 3 Lymphocyte subpopulation of three STAT3 deficiency patient
From: The clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations
P4 (%) | P8(%) | P9 (%) | |
|---|---|---|---|
Cytotoxic T cell (CD8, CD45+CD3+CD8+) | |||
Central memory cytotoxic T cells (CD8 CM, CD3+CD8+CD45RA−CD27+) | 10.40 (6.66–34.14) | 19.20 (4.82–24.11) | 9.00 (12.08–30.54) |
Naive differentiated cytotoxic T cells (CD8 Naive, CD3+CD8+CD45RA+CD27+) | 67.30 (38.19–86.18) | 50.50 (47.36–92.45) | 36.20 (41.58–77.90) |
Effector memory cytotoxic T cells (CD8 EM, CD3+CD8+CD45RA−CD27−) | 5.90 (0.60–12.01) | 17.9↑ (0.20–8.94) | 6.20 (1.58–13.18) |
Terminally differentiated effector memory cytotoxic T cells (CD8 TEMRA, CD3+CD8+CD45RA+CD27−) | 16.40 (0.50–24.45) | 12.40 (0.15–28.32) | 48.6↑ (1.70–24.62) |
CD4 T cell (CD45+CD3+CD4+) | |||
Central memory helper T cells (CD4 CM, CD3+CD4+CD45RA−CD27+) | 21.80 (17.12–47.60) | 32.20 (10.15–33.38) | 19.50 (22.06–46.46) |
Naive differentiated helper T cells (CD4 Naive, CD3+CD4+CD45RA+CD27+) | 75.80 (46.42–81.20) | 65.40 (59.28–88.09) | 76.30 (45.56–75.28) |
Effector memory helper T cells (CD4 EM, CD3+CD4+CD45RA−CD27−) | 2.30 (0.90–5.17) | 2.00 (0.42–3.96) | 4.10 (2.08–8.78) |
Terminally differentiated effector memory helper T cells (CD4 TEMRA, CD3+CD4+CD45RA+CD27−) | 0.00 (0.00–0.50) | 0.40 (0.00–1.49) | 0.10 (0.00–1.06) |
γδ T cells (γδ T, CD3+TCRγδ+) | 0↓ (5.07–17.60) | 4.80 (3.95–10.40) | 21 (6.92–19.84) |
TCRαβ+ double-negative T (DNT) cells (CD3+TCRαβ+CD4−CD8−) | 3.3↑ (0.56–2.36) | 5.6↑ (0.41–1.55) | 21.2↑ (0.18–2.81) |
B cells (CD45+CD19+) | |||
Memory B (CD19+CD27+IgD−) | 2.50↓ (3.60–18.55) | 0.40↓ (1.77–7.06) | 3.80↓ (7.76–19.90) |
Naïve B (CD19+CD27–IgD+) | 91.60↑ (59.59–85.28) | 96.70↑ (75.28–92.77) | 63.80 (48.36–75.84) |
Transitional B (CD19+CD24++CD38++) | 3.80 (4.73–15.68) | 29.90↑ (6.04–21.62) | 5.30 (2.58–12.30) |
Plasmablasts (CD19+CD24−CD38++) | 2.40 (0.60–10.31) | 0.90 (0.71–5.88) | 3.90 (0.90–7.36) |