Table 1 Diagnosis, causal as well as tolerated β-lactam antibiotic in 205 patients with β-lactam hypersensitivity
Immediate-type hypersensitivity (n = 70) | Delayed-type hypersensitivity (n = 135) | |
|---|---|---|
Males/females | 28 / 42 | 48 / 87 |
Median age (range, years) | 47 (11–76) | 50 (7–83] |
Anaphylaxis | ||
Mild | 26 | n.a. |
Moderate | 27 | |
Severe | 17 | |
Delayed reaction | ||
Measles-like exanthem | n.a. | 117 |
SDRIFE | 12 | |
FDE | 3 | |
DRESS | 3 | |
Causal β-lactam antibiotic | ||
Aminopenicillin (amoxicillin or ampicillin) | 3 | 91 |
Aminopenicillin + benzyl penicillin | 2 | 36 |
Cefuroxime | 12 | 2 |
Cefazolin | 9 | 0 |
Ceftriaxone | 4 | 1 |
Cefaclor | 4 | 0 |
Several cephalosporins | 18 | 1 |
Cephalosporin + aminopenicillin | 12 | 0 |
Benzyl / phenoxymethyl penicillin | 3 | 3 |
Piperacillin + tazobactam | 3 | 0 |
Flucloxacillin | 0 | 1 |
Tolerated β-lactam antibiotics (several different β-lactams per case possible) | ||
Aminopenicillin (amoxicillin or ampicillin) | 31 | 4 |
Cephalosporin | 58 | 179 |
Phenoxymethyl penicillin | 32 | 48 |