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Table 1 2010 World Allergy Organization (WAO) subcutaneous immunotherapy systemic reaction grading system

From: A single centre retrospective study of systemic reactions to subcutaneous immunotherapy

WAO systemic reaction grade Reaction characteristics
1 Symptoms from one organ system, excluding asthma, gastrointestinal symptoms or cardiovascular symptoms
2 Asthma, gastrointestinal symptoms or cardiovascular symptoms
3 Patients with symptoms from multiple organ systems, or throat tightness/discomfort suggestive of upper airway edema
4 Hypotension (systolic blood pressure of less than 90 mmHg or less than 30% of baseline) or respiratory failure
5 Death
  1. mmHg millimeter of mercury