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Table 3 Crude and adjusted hazard ratios (95% confidence interval) of asthma for otitis media according to frequency of otitis media

From: Bidirectional association between asthma and otitis media in children

Characteristics HRs for otitis media
Crudea P-value Adjustedab P-value
Otitis media ≥ 2times
Asthma 1.60 (1.52–1.68)  < 0.001* 1.60 (1.52–1.68)  < 0.001*
Control I 1.00   1.00  
Otitis media ≥ 3 times
Asthma 1.64 (1.54–1.74)  < 0.001* 1.57 (1.48–1.67)  < 0.001*
Control I 1.00   1.00  
Otitis media ≥ 4 times
Asthma 1.71 (1.59–1.83)  < 0.001* 1.63 (1.52–1.75)  < 0.001*
Control I 1.00   1.00  
Otitis media ≥ 5 times
Asthma 1.72 (1.58–1.86)  < 0.001* 1.63 (1.50–1.77)  < 0.001*
Control I 1.00   1.00  
  1. * Cox-proportional hazard regression model, Significance at P < 0.05
  2. aStratified model for age, income, and region of residence
  3. bAdjusted model for atopic dermatitis and chronic sinusitis