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Table 3 Crude and adjusted hazard ratios (95% confidence interval) of asthma for otitis media according to frequency of otitis media

From: Bidirectional association between asthma and otitis media in children

Characteristics

HRs for otitis media

Crudea

P-value

Adjustedab

P-value

Otitis media ≥ 2times

Asthma

1.60 (1.52–1.68)

 < 0.001*

1.60 (1.52–1.68)

 < 0.001*

Control I

1.00

 

1.00

 

Otitis media ≥ 3 times

Asthma

1.64 (1.54–1.74)

 < 0.001*

1.57 (1.48–1.67)

 < 0.001*

Control I

1.00

 

1.00

 

Otitis media ≥ 4 times

Asthma

1.71 (1.59–1.83)

 < 0.001*

1.63 (1.52–1.75)

 < 0.001*

Control I

1.00

 

1.00

 

Otitis media ≥ 5 times

Asthma

1.72 (1.58–1.86)

 < 0.001*

1.63 (1.50–1.77)

 < 0.001*

Control I

1.00

 

1.00

 
  1. * Cox-proportional hazard regression model, Significance at P < 0.05
  2. aStratified model for age, income, and region of residence
  3. bAdjusted model for atopic dermatitis and chronic sinusitis