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Table 2 Change from baseline (expressed as a ratio) in 24-h weighted mean SC at week 6

From: A randomized, double-blind, placebo-controlled, parallel-group study of once-daily inhaled fluticasone furoate on the hypothalamic–pituitary–adrenocortical axis of children with asthma

Variables

Placebo group

FF 50 QD group

SC population

 N

51

53

 n

50

52

 LS geometric mean (nmol/L)

173.25

160.65

 LS ratio to baseline

1.05

0.97

 FF 50 QD/placebo ratio

0.93

 95% CI

0.8096, 1.0620

ITT population

 N

55

56

 n

51

53

 LS geometric mean (nmol/L)

174.08

159.98

 LS ratio to baseline

1.06

0.97

 FF 50 QD/placebo ratio

0.92

 95% CI

0.8040, 1.0505

  1. CI confidence interval, FF 50 QD fluticasone furoate 50 µg once daily, h hours, ITT intent-to-treat, LS least squares, SC serum cortisol, N number of subjects in population, n number of subjects with value at the visit