Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation

Table 1 Mannitol compared to methacholine deep inhalation studies

	Refs		n	Asthma definition	n	Non-asthma definition
	Author	Ref	n	Asthma definition	n	Non-asthma definition
1	Anderson et al.	[3]	25	Asthma with indirect AHR to hypertonic saline	0
2	Pjorsgerg et al.	[4]	0		16	Asymptomatic positive MCT
3	Miedinger et al.	[5]	14	Asthma defined by board physician from 101 Swiss firefighters	87	Defined by board MD
4	Pjorsberg et al.	[6]	53	Asthmatics not using ICS	0
5	Anderson et al.	[7]	240	240 of 375 with symptoms and unconfirmed asthma diagnosis made by AHR-blinded physician	135	Defined by AHR-blinded physician
6	Gade et al.	[8]	48	Asthmatics same day tests in random order 21 using ICS	0
7	Miedinger et al.	[9]	42	Doctor diagnosed (MD-Dx) asthma 235 Swiss armed forces conscripts	193	Non-asthmatic conscripts
8	Sverrild et al.	[10]	51	From 238 randomly selected subjects Dx by physician blinded to AHR results	187	Blinded physician
9	Cancelliere et al.	[11]	11	From 28 with asthma-like Sx Dx defined by positive AHR	17	Defined by negative AHR
10	Manoharan et al.	[12]	123	MD-Dx asthma	0
11	Kim et al.	[13]	50	MD-Dx asthma	54	Normal controls
12	Backer et al.	[14]	122	From 190 referred for possible asthma Dx by panel without AHR results	68	Defined by panel without AHR results
13	Park et al.	[15]	134	Asthmatic children 32 using ICS	0

ISSN: 1710-1492