Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation

Table 4 Mannitol compared to methacholine tidal breathing methods and results

	MCH Method	Definition of positive MCH	Asthma		Asthma		Non asthma		Non asthma
	MCH Method	Definition of positive MCH	MCH +ve	MCH total	MAN +ve	MAN total	MCH +ve	MCH total	MAN +ve	MAN total
1	2 min TB (ref Cockcroft et al [34])	PC20 ≤ 16 mg/mL	25	25	21	25	0	10	0	10
2	Spira tidal dosimeter	PD20 ≤ 1 mg^a (Hist.)	30	37	19	37
3	Spira tidal dosimeter	PD20 ≤ 1814 μg^a	4	10	2	10	19	48	1	48
4	TB (ref Cockcroft et al [34])	PC20 ≤ 16 mg/mL	29	30	13	30
5	Jaeger tidal dosimeter	PD20 ≤ 2 mg^a	27	34	13	34	3	18	0	18
6	2 min TB (ref Cockcroft et al [34])	PC20 ≤ 16 mg/mL	22	30	9	30
7	TB (ref Cockcroft et al [34])	PC20 ≤ 8 mg/mL	18	23	10	23
8	Spira tidal dosimeter	PD20 ≤ 8 μmol^a	15	16	9	18	1	39	3	39
9	TB (ref Cockcroft et al [34])	PC20 ≤ 16 mg/mL	42	67	43	67	3	21	0	21
10	2 min TB (ref Cockcroft et al [34])	PC20 ≤ 16 mg/mL	131	141	7	77	1	30	0	21
11	2 min TB (3 studies) [34]	PC20 ≤ 16 mg/mL	25	26	11	26
12	Solo TB (1.5–2.5 min) [35]	PD20 ≤ 400 μg	20	20	11	20
	Total %		343 83.1%	413	146 41.5%	351	27 16.2%	166	4 2.5%	157

ISSN: 1710-1492