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Table 4 Mannitol compared to methacholine tidal breathing methods and results

From: Comparison of methacholine and mannitol challenges: importance of method of methacholine inhalation

 MCH MethodDefinition of positive MCHAsthmaAsthmaNon asthmaNon asthma
MCH +veMCH totalMAN +veMAN totalMCH +veMCH totalMAN +veMAN total
12 min TB (ref Cockcroft et al [34])PC20 ≤ 16 mg/mL25252125010010
2Spira tidal dosimeterPD20 ≤ 1 mga (Hist.)30371937    
3Spira tidal dosimeterPD20 ≤ 1814 μga4102101948148
4TB (ref Cockcroft et al [34])PC20 ≤ 16 mg/mL29301330    
5Jaeger tidal dosimeterPD20 ≤ 2 mga27341334318018
62 min TB (ref Cockcroft et al [34])PC20 ≤ 16 mg/mL2230930    
7TB (ref Cockcroft et al [34])PC20 ≤ 8 mg/mL18231023    
8Spira tidal dosimeterPD20 ≤ 8 μmola1516918139339
9TB (ref Cockcroft et al [34])PC20 ≤ 16 mg/mL42674367321021
102 min TB (ref Cockcroft et al [34])PC20 ≤ 16 mg/mL131141777130021
112 min TB (3 studies) [34]PC20 ≤ 16 mg/mL25261126    
12Solo TB (1.5–2.5 min) [35]PD20 ≤ 400 μg20201120    
 Total
%
 343
83.1%
413146
41.5%
35127
16.2%
1664
2.5%
157
  1. aPD20 calculated cumulatively