Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese

Table 2 Genotype frequencies of cases and controls and their associations with AR risk under co-dominant genetic model

Gene	SNP ID	Genotype	Case		Control		P (2 df)^a	Logistic Regression		Armitage’s trend test
Gene	SNP ID	Genotype	No.	Frequency (%)	No.	Frequency (%)	P (2 df)^a	OR (95% CI)	P^b	Armitage’s trend test
LPP	rs9865818	AA	325	42.71	361	47.50	0.052	1.000 (referent)		0.018
		GA	335	44.02	324	42.63		1.127 (0.903–1.407)	0.29
		GG	101	13.27	75	9.87		1.469 (1.041–2.074)	0.029
DNAH5	rs6554809	CC	541	71.18	593	78.03	0.006	1.000 (referent)		0.007
		TC	206	27.11	153	20.13		1.597 (1.246–2.048)	0.000
		TT	13	1.71	14	1.84		1.235 (0.558–2.732)	0.603
WDR36-CAMK4	rs1438673	TT	221	29.31	250	33.03	0.029	1.000 (referent)		0.014
		TC	382	50.66	393	51.92		1.045 (0.824–1.324)	0.718
		CC	151	20.03	114	15.06		1.396 (1.021–1.908)	0.037
HLA-DQB1-HLA-DQB2	rs7775228	TT	422	55.60	493	64.95	0.001	1.000 (referent)		0.001
		TC	275	36.23	216	28.46		1.589 (1.263–1.999)	0.000
		CC	62	8.17	50	6.59		1.500 (0.996–2.259)	0.052
CLEC16A	rs7203459	TT	633	83.07	604	79.58	0.177	1.000 (referent)		0.123
		TC	120	15.75	147	19.37		0.731 (0.555–0.962)	0.025
		CC	9	1.18	8	1.05		0.962 (0.355–2.603)	0.939

Italic values indicate significance of P value (P < 0.05)
^aGlobal P values [2 degrees of freedom (df)]: genotype frequencies in AR and control group were compared using a χ² test with 2 df
^bP values from unconditional logistic regression analyses, adjusted for age and gender

ISSN: 1710-1492