Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese

Table 4 Functional annotation of positive SNPs in HaploReg v4.1 tool

SNP	Frequence in 1000 Genomes				Association phenotype with GWAS	eQTL	Histone markers
SNP	AFR	AMR	ASN	EUR	Association phenotype with GWAS	eQTL	Histone markers
rs9865818	0.11	0.37	0.33	0.42	Allergic sensitization [11]	NA	H3K4me1_Enh H3K27ac_Enh
rs7617456	0.21	0.47	0.24	0.40	IgE grass sensitization [10]	NA	H3K4me3_Pro
rs6554809	0.49	0.25	0.12	0.16	IgE grass sensitization [10]	NA	H3K4me1_Enh
rs1438673	0.84	0.6	0.54	0.52	Asthma and hay fever [21] Self-reported allergy [12]	TSLP	H3K4me1_Enh
rs7775228	0.17	0.2	0.28	0.15	Asthma [22] IgE grass sensitization [10]	HLA-DPA1/HLA-DPA2/HLA-DQB1/HLA-DQB2	H3K4me1_Enh
rs7203459	0.18	0.21	0.09	0.26	Self-reported allergy [12]	LOC642755, C16orf75/SOCS1	H3K4me1_Enh H3K27ac_Enh

AFR African, AMR Amerindian, ASN Asian, EUR European, eQTL Expression quantitative trait loci, NA not available because of the lack of data

ISSN: 1710-1492