Fig. 2

Timeline. Timeline of symptoms, drug exposure and treatment, including C-reactive protein (CRP) levels (dark grey line, normal range: < 5 mg/l, scale on the left side), total leukocyte count (light grey line, normal range: 3.9–10.5 /nl, scale on the right side) and percentage of CD4⁺CD8⁺ T cells (among total T cells) in peripheral blood (PB, orange) and blister fluid (BF, red). When percentage of CD4⁺CD8⁺ T cells was determined by two panels at the same day, the mean was calculated. Dosage of medication was 2 × 875/125 mg/d for amoxicillin-clavulanic acid (AMC), 2 × 250 mg/d for clarithromycin (CLR) and 2 × 500 mg/d for levofloxacin (LVX). Paracetamole, ibuprofen, and metamizole were taken successively, however, exact dosage could not be evaluated retrospectively. Further abbreviations: CAP: community-aquired pneumonia, EMM: Erythema multiforme majus, d: day, w: week, y: year