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Table 4 Methylation sites in promoter region of ADAM33

From: Interaction between early-life pet exposure and methylation pattern of ADAM33 on allergic rhinitis among children aged 3–6 years in China

Target

Position

Type

P-value (Utest)

FDR P-value

(Utest)

OR(L95-U95) (logistic)

AUC (logistic)

MethylDiff

Mean in AR

Mean in control

ADAM33_1

45

CG

0.052

0.475

0.9761 (0.9549–0.9978)

0.592

− 0.05618

0.21179

0.26797

ADAM33_1

85

CG

0.040

0.456

0.9567 (0.9024–1.0143)

0.598

− 0.01416

0.73703

0.75119

ADAM33_1

87

CG

0.055

0.475

1.0328 (0.995–1.072)

0.619

− 0.04202

0.77197

0.81399

ADAM33_1

89

CG

0.049

0.475

1.009 (0.9988–1.0193)

0.593

− 0.09300

0.35000

0.44300

ADAM33_1

109

CG

0.057

0.475

0.8988 (0.8054–1.003)

0.590

− 0.00904

0.46346

0.47250

ADAM33_1

131

CG

0.047

0.462

0.9215(0.8309–1.022)

0.594

− 0.00761

0.46077

0.46838

ADAM33_1

148

CG

0.046

0.462

0.9051 (0.7932–1.0328)

0.594

− 0.00564

0.33127

0.33692

ADAM33_1

171

CG

0.044

0.459

0.9589 (0.8777–1.0477)

0.595

− 0.00518

0.33279

0.33797

ADAM33_1

173

CG

0.042

0.459

0.6178 (0.4049–0.9426)

0.603

− 0.00498

0.00858

0.01357

ADAM33_1

176

CG

0.053

0.475

0.8126 (0.6548–1.0083)

0.592

− 0.00456

0.05248

0.05704

ADAM33_2

26

CG

0.045

0.460

0.5744 (0.3513–0.9392)

0.601

− 0.00304

0.00577

0.00881

ADAM33_2

30

CG

0.051

0.475

0.5615 (0.3543–0.8898)

0.593

− 0.00301

0.01210

0.01512

ADAM33_2

38

CG

0.040

0.456

0.7737 (0.5536–1.0813)

0.597

− 0.00231

0.01141

0.01372

ADAM33_2

46

CG

0.044

0.459

0.4853 (0.243–0.9691)

0.598

− 0.00222

0.00628

0.00851

ADAM33_2

51

CG

0.053

0.475

0.5236 (0.2937–0.9335)

0.592

− 0.00207

0.01878

0.02086

ADAM33_2

56

CG

0.039

0.456

0.7242 (0.4734–1.108)

0.597

− 0.00181

0.00791

0.00972

ADAM33_2

66

CG

0.058

0.475

0.1676 (0.0344–0.8158)

0.623

− 0.00162

0.00684

0.00846

ADAM33_2

69

CG

0.053

0.475

0.8777 (0.6093–1.2642)

0.592

− 0.00098

0.00792

0.00889

ADAM33_2

109

CG

0.041

0.458

0.122 (0.0229–0.6488)

0.597

− 0.00087

0.00635

0.00721

ADAM33_2

132

CG

0.038

0.456

0.7905(0.4372–1.4293)

0.601

− 0.00071

0.00693

0.00764

ADAM33_2

134

CG

0.058

0.475

0.4438 (0.1491–1.3204)

0.590

− 0.00070

0.00511

0.00582

ADAM33_2

137

CG

0.055

0.475

1.5811 (1.081–2.3123)

0.597

0.00475

0.01382

0.00908

  1. Target, the name of the amplicon; POS, the specific location of the methylation site in the amplicon; P value (U-test): the U-test model is used to calculate the P value; OR (L95–U95) (logistic), AUC (logistic), odds ratio and area under curve was calculated through the logistic regression model; mean in AR, average methylation degree of the AR group; mean in control, average methylation degree of the control group; MethylDiff, average methylation degree of the AR group minus average methylation degree of the control group
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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