Interaction between early-life pet exposure and methylation pattern of ADAM33 on allergic rhinitis among children aged 3–6 years in China

Table 6 Multiple regression analysis for analyzing the relationship among risk factors, the methylation level of ADAM33 and AR, AR as the dependent variable

Risk factor	β	OR (95% CI)	P-value
Maternal allergic history^a	0.561	1.752 (0.817–3.761)	0.150
Exposed to pet^a	0.721	2.057 (1.029–4.109)	0.001
Methylation level^b	− 0.225	0.799 (0.645–1.006)	0.114
Methylation level × exposed to pet	0.353	1.423 (1.007–1.639)	0.005
Methylation level × maternal allergic history	− 0.212	0.809 (0.699–1.105)	0.169

Adjusted for gender, age, height, weight, season of birth and exposure to second-hand smoke
OR odds ratio, CI confidence interval
^a0 = without, 1 = with
^bMethylation levels were rescaled to rank

ISSN: 1710-1492