Fig. 1From: Autoantibodies to speckled protein family in primary biliary cholangitis Multiple nuclear dot staining pattern by indirect immunofluorescence on HEp-2 cells (magnification 20). Anti-multiple nuclear dots react with 3–20 nuclear dots distinct from nucleoli and from the anticentromere targets. Punctate staining of chromosomes in mitosis clearly distinguishes anticentromere from anti-multiple nuclear dotsBack to article page