Table 1 Algorithm definitions for initial study cohorts

Probable HAE

≥ 2 ICD-9-CM/ICD-10-CM diagnosis codes^a on separate days and no mention of HAE in physician notes OR

≥ 2 mentions of HAE in physician notes on separate days and no diagnosis code^a OR

 ≥ 1 diagnosis code^a and ≥ 1 mention of HAE in physician notes

Suspected HAE

Only 1 diagnosis code^a OR

Only 1 mention of HAE in physician notes and no diagnosis code^a