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Table 2 Demographic, clinical, and functional characteristics of the patients

From: Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Clinical features Eosinophilic allergic asthma, n = 22 Eosinophilic non-allergic asthma, n = 17 Non-eosinophilic allergic asthma, n = 66 Non-eosinophilic non-allergic asthma, n = 66 P
Sex, n (M/F) 8/14 4/13 19/47 19/47 0.845
Age (years), means ± SD 33.9 ± 13.5* 39.2 ± 14.1 38.6 ± 12.8* 45.5 ± 12.9 0.001
Body mass index (kg/m2), means ± SD 25.3 ± 4.7 23.3 ± 3.7 24.1 ± 3.6 25.5 ± 4.3 0.086
Manifestation, n (%)
 CA 19 (86.4%) 15 (88.2%) 41 (62.1%) 30 (45.5%)  < 0.001
 CVA 2 (9.0%) 2 (11.8%) 25 (37.9%) 35 (53.0%)  
 CTVA 1 (4.6%) 0 1 (1.5%) 0  > 0.99
Exercise-induced asthma, n (%) 0 0 1(1.5%) 1(1.5%)  > 0.99
Average time to diagnosis (months), median 36.3 25.5 32.9 44.5 0.075
Comorbidity and history, n (%)
 Rhinitis/nasosinusitis 7 (31.8%) 6 (35.3%) 13 (19.7%) 8 (12.1%) 0.072
 Other allergic diseasesa 7 (31.8%) 2 (11.8%) 25 (25.8%) 17 (25.8%) 0.154
 Other diseasesb 4 (18.2%) 4 (23.5%) 35 (53.0%) 22 (33.3%) 0.007
Obesity 7 (31.8%) 1 (4.5%) 8 (12.1%) 19 (28.8%) 0.022
Smoking history, n (%) 3 (13.6%) 4 (23.5%) 7 (10.6%) 11 (16.7%) 0.486e
Family history of allergic diseases 2 (9.1%) 3 (17.6%) 13 (19.7%) 5 (7.6%) 0.188
Laboratory tests
 Eosinophil count induced sputum (%), median (IQR) 23.65 (14.65–39.88) 59.47 (23.40–86.40) 0.34 (0–1.53)cd 0.28 (0–1.50)cd  < 0.001
 Neutrophil count induced sputum (%), median (IQR) 43.62 (30.70–53.15) 35.64 (10.45–42.52) 76.5 cd (57.73–89.96) 79.54 (59.36–93.81)cd  < 0.001
 Neutrophil count induced sputum (%), median (IQR) 43.62 (30.70–53.15) 35.64 (10.45–42.52) 76.5 cd (57.73–89.96) 79.54 (59.36–93.81)cd  < 0.001
 Total IgE serum, IU/mL, means ± SD 237.50 ± 13.76 130.24 ± 20.58 100.25 ± 10.43 80.65 ± 20.54 0.188
 Eosinophil count peripheral blood (109/L), median, IQR 0.35 (0.23–064) 0.49 (0.28–1.54) 0.11 (0.06–0.24)cd 0.11 (0.07–0.23)cd  < 0.001
 Eosinophils in peripheral blood (%), median (IQR) 5.8 (3.3–8.8) 7.8 (5.85–14.33) 1.7 (0.98–3.65)cd 1.75 (1.05–2.85)cd  < 0.001
  1. CA; classical asthma; CVA: cough variant asthma; CTVA: chest tightness variant asthma; IQR: interquartile range
  2. aIncluding urticaria, eczema, allergic dermatitis, drug allergy, and food allergy
  3. bIncluding anxiety, depression, and sleep apnea–hypopnea syndrome
  4. cP < 0.001 vs. patients with eosinophilic allergic asthma
  5. dP < 0.001 vs. patients with eosinophilic non-allergic asthma
  6. *P < 0.05 vs. patients with non-eosinophilic non-allergic asthma
  7. eFisher’s exact test