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Table 2 Demographic, clinical, and functional characteristics of the patients

From: Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Clinical features

Eosinophilic allergic asthma, n = 22

Eosinophilic non-allergic asthma, n = 17

Non-eosinophilic allergic asthma, n = 66

Non-eosinophilic non-allergic asthma, n = 66

P

Sex, n (M/F)

8/14

4/13

19/47

19/47

0.845

Age (years), means ± SD

33.9 ± 13.5*

39.2 ± 14.1

38.6 ± 12.8*

45.5 ± 12.9

0.001

Body mass index (kg/m2), means ± SD

25.3 ± 4.7

23.3 ± 3.7

24.1 ± 3.6

25.5 ± 4.3

0.086

Manifestation, n (%)

 CA

19 (86.4%)

15 (88.2%)

41 (62.1%)

30 (45.5%)

 < 0.001

 CVA

2 (9.0%)

2 (11.8%)

25 (37.9%)

35 (53.0%)

 

 CTVA

1 (4.6%)

0

1 (1.5%)

0

 > 0.99

Exercise-induced asthma, n (%)

0

0

1(1.5%)

1(1.5%)

 > 0.99

Average time to diagnosis (months), median

36.3

25.5

32.9

44.5

0.075

Comorbidity and history, n (%)

 Rhinitis/nasosinusitis

7 (31.8%)

6 (35.3%)

13 (19.7%)

8 (12.1%)

0.072

 Other allergic diseasesa

7 (31.8%)

2 (11.8%)

25 (25.8%)

17 (25.8%)

0.154

 Other diseasesb

4 (18.2%)

4 (23.5%)

35 (53.0%)

22 (33.3%)

0.007

Obesity

7 (31.8%)

1 (4.5%)

8 (12.1%)

19 (28.8%)

0.022

Smoking history, n (%)

3 (13.6%)

4 (23.5%)

7 (10.6%)

11 (16.7%)

0.486e

Family history of allergic diseases

2 (9.1%)

3 (17.6%)

13 (19.7%)

5 (7.6%)

0.188

Laboratory tests

 Eosinophil count induced sputum (%), median (IQR)

23.65 (14.65–39.88)

59.47 (23.40–86.40)

0.34 (0–1.53)cd

0.28 (0–1.50)cd

 < 0.001

 Neutrophil count induced sputum (%), median (IQR)

43.62 (30.70–53.15)

35.64 (10.45–42.52)

76.5 cd (57.73–89.96)

79.54 (59.36–93.81)cd

 < 0.001

 Neutrophil count induced sputum (%), median (IQR)

43.62 (30.70–53.15)

35.64 (10.45–42.52)

76.5 cd (57.73–89.96)

79.54 (59.36–93.81)cd

 < 0.001

 Total IgE serum, IU/mL, means ± SD

237.50 ± 13.76

130.24 ± 20.58

100.25 ± 10.43

80.65 ± 20.54

0.188

 Eosinophil count peripheral blood (109/L), median, IQR

0.35 (0.23–064)

0.49 (0.28–1.54)

0.11 (0.06–0.24)cd

0.11 (0.07–0.23)cd

 < 0.001

 Eosinophils in peripheral blood (%), median (IQR)

5.8 (3.3–8.8)

7.8 (5.85–14.33)

1.7 (0.98–3.65)cd

1.75 (1.05–2.85)cd

 < 0.001

  1. CA; classical asthma; CVA: cough variant asthma; CTVA: chest tightness variant asthma; IQR: interquartile range
  2. aIncluding urticaria, eczema, allergic dermatitis, drug allergy, and food allergy
  3. bIncluding anxiety, depression, and sleep apnea–hypopnea syndrome
  4. cP < 0.001 vs. patients with eosinophilic allergic asthma
  5. dP < 0.001 vs. patients with eosinophilic non-allergic asthma
  6. *P < 0.05 vs. patients with non-eosinophilic non-allergic asthma
  7. eFisher’s exact test
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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