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Table 3 Comparison of pulmonary functions and FeNO levels among the four endotypes

From: Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Indicators

Eosinophilic allergic asthma, n = 22

Eosinophilic non-allergic asthma, n = 17

Non-eosinophilic allergic asthma, n = 66

Non-eosinophilic non-allergic asthma, n = 66

P

FEV1%

 (χ ± s)

97.15 ± 25.45a

81.55 ± 28.25

111.09 ± 20.92ab

104.66 ± 18.75a

 < 0.001

FEF25%

 (χ ± s)

80.86 ± 39.74a

67.22 ± 38.30

108.82 ± 30.95ab

101.97 ± 30.01a

 < 0.001

FEF50%

 (χ ± s)

74.71 ± 44.13a

52.42 ± 30.97

99.67 ± 38.98ab

94.84 ± 35.28a

 < 0.001

FEF75%

 (χ ± s)

70.10 ± 42.51a

44.82 ± 27.90

79.52 ± 36.89ab

74.75 ± 31.78a

0.004

FEF25-75%

 (χ ± s)

69.83 ± 39.61a

48.50 ± 29.13

87.45 ± 34.68ab

83.53 ± 30.47a

 < 0.001

Large airway dysfunction

 n (%)

10 (45.5)

15 (88.2)

10 (15.2)

18 (27.3)

 < 0.001

Small airway dysfunction

 n (%)

12 (54.5)

10 (58.8)

30 (45.5)

28 (42.4)

0.5574

FeNO

 Median (IQR)

58 (21.5–112.5)

76 (64.75–97.75)

20 (13.5–37.5)ab

22.5 (13.75–37.75)ab

 < 0.001

  1. FEV1%: forced expiratory volume in one second as a percentage of expected value; FEF25%: forced expiratory flow at 25% vital capacity; FEF50%: forced expiratory flow at 50% vital capacity; FEF75%: forced expiratory flow at 75% vital capacity; FEF25–75%: forced expiratory flow at 25–75% vital capacity; FeNO: fractional exhaled nitric oxide; 1 ppb = l × 10–9; FEV: forced expiratory volume
  2. aP < 0.05 vs. patients with eosinophilic non-allergic asthma
  3. bP < 0.05 vs. patients with eosinophilic allergic asthma