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Table 3 Comparison of pulmonary functions and FeNO levels among the four endotypes

From: Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Indicators Eosinophilic allergic asthma, n = 22 Eosinophilic non-allergic asthma, n = 17 Non-eosinophilic allergic asthma, n = 66 Non-eosinophilic non-allergic asthma, n = 66 P
FEV1%
 (χ ± s) 97.15 ± 25.45a 81.55 ± 28.25 111.09 ± 20.92ab 104.66 ± 18.75a  < 0.001
FEF25%
 (χ ± s) 80.86 ± 39.74a 67.22 ± 38.30 108.82 ± 30.95ab 101.97 ± 30.01a  < 0.001
FEF50%
 (χ ± s) 74.71 ± 44.13a 52.42 ± 30.97 99.67 ± 38.98ab 94.84 ± 35.28a  < 0.001
FEF75%
 (χ ± s) 70.10 ± 42.51a 44.82 ± 27.90 79.52 ± 36.89ab 74.75 ± 31.78a 0.004
FEF25-75%
 (χ ± s) 69.83 ± 39.61a 48.50 ± 29.13 87.45 ± 34.68ab 83.53 ± 30.47a  < 0.001
Large airway dysfunction
 n (%) 10 (45.5) 15 (88.2) 10 (15.2) 18 (27.3)  < 0.001
Small airway dysfunction
 n (%) 12 (54.5) 10 (58.8) 30 (45.5) 28 (42.4) 0.5574
FeNO
 Median (IQR) 58 (21.5–112.5) 76 (64.75–97.75) 20 (13.5–37.5)ab 22.5 (13.75–37.75)ab  < 0.001
  1. FEV1%: forced expiratory volume in one second as a percentage of expected value; FEF25%: forced expiratory flow at 25% vital capacity; FEF50%: forced expiratory flow at 50% vital capacity; FEF75%: forced expiratory flow at 75% vital capacity; FEF25–75%: forced expiratory flow at 25–75% vital capacity; FeNO: fractional exhaled nitric oxide; 1 ppb = l × 10–9; FEV: forced expiratory volume
  2. aP < 0.05 vs. patients with eosinophilic non-allergic asthma
  3. bP < 0.05 vs. patients with eosinophilic allergic asthma