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Table 4 Clinical characteristics of patients between asthma and asthma-COPD overlap

From: Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes

 

Asthma

ACO

p value

N

103

129

 

Sex (M/F)

52/65

56/58

0.476

Age (y)

42 ± 14

56 ± 8

< 0.001

BMI

24.1 ± 3.7

23.7 ± 3.0

0.664

NA, N (%)

4 (40%)

6 (60%)

0.514

EA, N (%)

45 (50.6%)

44 (49.4%)

0.514

MGA, N (%)

4 (33.3%)

8 (66.7%)

0.514

PGA, N (%)

64 (53.3%)

56 (46.7%)

0.514

Smoking history

< 0.001

 Never smoker, N (%)

80 (68.4%)

53 (46.5%)

 

 Current smoker, N (%)

13 (11.1%)

36 (31.6%)

 

 Ex-smoker, N (%)

24 (20.5%)

25 (21.9%)

 

Pack-years

0 (0, 3.3)

5.2 (0, 25.0)

< 0.001

Diagnosis age (y)

38 ± 13

50 ± 12

< 0.001

Asthma diagnosed more than 1 year, N (%)

59 (53.6%)

75 (69.4%)

0.016

Severe asthma, N (%)

48 (42.1%)

41 (37.6%)

0.494

Atopy (Y/N)

19/34

18/47

0.342

ICS dose

0 (0, 400)

250 (0, 400)

0.032

Post-FEV1/FVC, %

77.7 ± 8.8

58.0 ± 8.9

< 0.001

Post-FEV1% predicted

93.5 ± 19.9

69.7 ± 21.2

< 0.001

FeNO (ppd)

42.5 (23.3, 88.9)

39.2 (22.9, 63.4)

0.249

ACQ6

1.4 (0.5, 2.1)

1.5 (0.7, 2.2)

0.020

ACT

18.0 (14.0, 22.0)

16.0 (13.0, 20.0)

0.010

Global AQLQ

5.2 (4.2, 6.1)

5.0 (4.2, 5.8)

0.081

HAD

3.5 (0.0, 10.0)

2.0 (0.0, 10.0)

0.476

Blood eosinophils, 109/L

0.3 (0.1, 0.5)

0.2 (0.1, 0.6)

0.792

Blood neutrophils, 109/L

4.6 (3.9, 5.8)

3.7 (3.2, 5.0)

0.429

Blood lymphocytes, 109/L

2.0 (1.5, 2.5)

2.1 (1.8, 2.8)

0.089

Blood monocytes, 109/L

0.5 (0.4, 0.6)

0.5 (0.4, 0.7)

0.021

Sputum TCC (106/mL)

2.7 (1.0, 5.0)

3.0 (1.9, 5.7)

0.031

Sputum macrophages, %

86.0 (59.7, 96.5)

82.0 (49.9, 93.7)

0.092

Sputum neutrophils, %

0.75 (0.0, 5.2)

1.6 (0.0, 11.5)

0.024

Sputum eosinophils, %

1.9 (0.3, 7.9)

2.5 (0.4, 7.5)

0.908

Sputum lymphocytes, %

1.3 (0.5, 3.8)

2.1 (0.5, 5.7)

0.184

  1. Data are presented as mean ± SD or median (IQR), unless otherwise indicated
  2. ACO Asthma-COPD overlap, NA neutrophilic asthma, EA eosinophilic asthma, MGA mixed granulocytic asthma, PGA paucigranulocytic asthma, IQR interquartile range