Table 2 upstream regulators associated with inflammatory response in hNECs exposed to 25 μg/ml O3BC+ 200 μg/ml pollen vs control hNECs
Upstream regulator | Expr Log Ratio | Activation z-score | p-value of overlap |
|---|---|---|---|
IL1B | 6.00 | 4.41 | 1.13E−14 |
CSF1 | 4.01 | 3.68 | 1.87E−12 |
CCL2 | 3.93 | 1.37 | 4.51E−10 |
TLR2 | 6.75 | 3.39 | 6.33E−08 |
LPL | 3.88 | 0.71 | 1.67E−07 |
IGF8 | 6.47 | 2.01 | 6.48E−07 |
SPP1 | 10.13 | 2.74 | 1.101E−06 |
CXCL8 | 5.57 | 2.29 | 9.69E−08 |
FCER1G | 3.21 | 2.11 | 0.0000018 |
IL1RN | 7.89 | − 2.61 | 3.07E−08 |