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Table 3 Desensitization protocol by CSII with a short-acting insulin. Adapted from Yuan et al.

From: The complexities of insulin allergy: a case and approach



Rate increasea

Target rate at the end of the day


0.01 IU/h of dilute insulinb

0.01 IU/h

0.24 IU/h


0.25 IU/h of non-dilute insulin

0.05 IU/h

1.4 IU/h


1.0 IU/hc

Add 4–6 IU to the bolus insulin infusion before each meal with the insulin pump


Give the bolus insulin by subcutaneous injection using a syringe, with a CSII basal insulin infusion administered at the same time

Stop using CSII and gave the patient insulin therapy by alternative multiple subcutaneous injections

  1. aCheck blood glucose levels and vitals q1h
  2. bShort-action insulin preparation was diluted 10 times (from U100 to U10 by saline)
  3. cAlternatively can decrease to 0.5 IU/h at night to avoid hypoglycemia in older patients