Table 4 Rapid desensitization protocol via subcutaneous insulin Glargine. Adapted from Hasani-Ranjbar et al.
From: The complexities of insulin allergy: a case and approach
Day | Dose | Time between doses | Recommendations |
|---|---|---|---|
1 | Administer 0.0001U, 0.001U, 0.01U, 0.1U, 1U | 30-min intervals | Check blood glucose levels and vitals q30 min |
2 | Administer 2U, 4U, 8U and 20U | 30-min intervals | In case of a local reaction, treat with an antihistamine and the last dose is repeated until no reaction occurs and then the dose increases are continued |
If there are systemic reactions, treat with epinephrine and an antihistamine. Reduce the dose to one half | |||
At high insulin doses, a 10% glucose solution can be given to counteract the glucose-lowering effect |