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Table 2 Associations between CBIgE elevation and the epidemiologic characteristics of the study subjects

From: Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children

Phenotypes

N (%)

Elevated rate of CBIgE

P value*

Maternal age (y)

  < 25

62 (6.4)

17 (27.4)

6.92 × 10–1

 25–29

500 (51.9)

128 (25.6)

 30–34

325 (33.7)

92 (28.3)

  ≥ 35

77 (8.0)

24 (31.2)

Maternal prepregnancy BMI (kg/m2)

  < 18.5

150 (15.6)

42 (28.0)

5.79 × 10–1

 18.5–24.9

694 (72.1)

182 (26.2)

 25–29.9

92 (9.6)

29 (31.5)

  ≥ 30

26 (2.7)

9 (34.6)

Maternal education

 Middle school or lower

28 (2.9)

6 (21.4)

5.48 × 10–1

 High school

112 (11.6)

27 (24.1)

 College or higher

825 (85.5)

230 (27.9)

Family income (CNY)

  < 100 K

273 (27.6)

74 (27.1)

9.98 × 10–1

  ≥ 100 K

540 (54.6)

146 (27.0)

 Unknown

176 (17.8)

48 (27.3)

Maternal atopya

 No

824 (86.5)

219 (26.6)

2.17 × 10–1

 Yes

129 (13.5)

41 (31.8)

Prenatal pet exposureb

 No

857 (89.1)

234 (27.3)

8.90 × 10–1

 Yes

105 (10.9)

28 (26.7)

Prenatal active or secondhand smoking

 No

577 (59.9)

158 (27.4)

9.32 × 10–1

 Yes

387 (40.1)

105 (27.1)

Parity

 None

868 (89.9)

235(27.1)

9.20 × 10–1

  ≥ 1

98 (10.1)

27 (27.6)

Previous pregnancy

 None

629 (65.1)

169 (26.9)

8.08 × 10–1

  ≥ 1

337 (34.9)

93 (27.6)

Gestational age (wk)

  < 37

33 (3.4)

7 (21.2)

 

 37–39

686 (71.0)

196 (28.6)

2.70 × 10–1

  ≥ 40

247 (25.6)

59 (23.9)

 

Season of birth

 Summer (Jun.—Aug.)

170 (17.7)

46 (27.1)

4.90 × 10–1

 Autumn (Sep.—Nov.)

451 (47.1)

131 (29.0)

 Winter (Dec.—Feb.)

337 (35.2)

85 (25.2)

Delivery mode

 Vaginal

229 (23.7)

50 (21.8)

3.93 × 10–2

 Cesarean section

737 (76.3)

212 (28.8)

Gender

 Boy

499 (51.7)

156 (31.3)

2.28 × 10–3

 Girl

466 (48.3)

105 (22.5)

Birth weight (g)

  < 2500

24 (2.5)

8 (33.3)

7.86 × 10–1

 2500–4000

857 (88.7)

231 (27.0)

  ≥ 4000

85 (8.8)

23 (27.1)

Antenatal complicationsc

 No

763 (81.2)

206 (27.0)

6.26 × 10–1

 Yes

177 (18.8)

51 (28.8)

  1. The missing data: maternal age (n = 25); maternal prepregnancy BMI (n = 27); maternal education (n = 24); maternal atopy (n = 36); prenatal pet exposure (n = 27); prenatal active or secondhand smoking (n = 25); parity (n = 23); previous pregnancy (n = 23); gestational age (n = 23); season of birth (n = 31); delivery mode (n = 23); gender (n = 24); birth weight (n = 23); antenatal complications (n = 49). The missing data were not from the same individuals for each variable
  2. CBIgE cord blood IgE
  3. aMaternal atopy was referred to those mothers who had asthma, allergic rhinitis or atopic dermatitis along with detectable specific IgE
  4. bKeeping cats or dogs at home during pregnancy
  5. cPregnancy hypertension, diabetes, infection or intrauterine growth retardation
  6. *χ2 test was used to analyze associations between CBIgE elevation and the epidemiologic characteristics
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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