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Table 3 Genetic effects of single SNPs on CBIgE elevation

From: Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children

SNP

CBIgE levels

Risk allele

Risk allele frequency, n (%)

P value *OR(95%CI)

Genotype frequency AA/AB/BB n (%)

Dominant

P value

OR(95%CI)

Recessive

P value

OR(95%CI)

IL13

    

CC/CT/TT

  

rs1800925

Elevated

T

102 (19.2)

5.17 × 10–2

170(63.9)/90(33.8)/6(2.3)

2.79 × 10–2

9.77 × 10–1

 

Normal

 

223 (15.5)

1.29 (1.00–1.67)

512(71.2)/191(26.6)/16(2.2)

1.40 (1.04–1.88)

1.01 (0.39–2.62)

IL13

    

GG/GA/AA

  

rs1295686

Elevated

A

204 (38.5)

2.73 × 10–3

97(36.6)/132(49.8)/36(13.6)

8.71 × 10–3

2.18 × 10–2

 

Normal

 

451 (31.3)

1.37 (1.12–1.69)

331(46.0)/327(45.4)/62(8.6)

1.47 (1.10–1.97)

1.67 (1.08–2.58)

IL13

    

CC/CT/TT

  

rs20541

Elevated

T

203 (38. 5)

3.57 × 10–3

97(36.7)/131(49.6)/36(13.6)

1.23 × 10–2

2.07 × 10–2

 

Normal

 

453 (31.5)

1.36 (1.11–1.68)

329(45.7)/329(45.7)/62(8.6)

1.45 (1.08–1.94)

1.68 (1.08–2.60)

IL4

    

TT/TC/CC

  

rs2243250

Elevated

C

109 (20.6)

7.55 × 10–1

168(63.4)/85(32.1)/12(4.5)

7.00 × 10–1

9.71 × 10–1

 

Normal

 

287 (19.9)

1.04 (0.81–1.33)

466(64.7)/221(30.7)/33(4.6)

1.06 (0.79–1.42)

0.99 (0.50–1.94)

ADRB2

    

AA/AG/GG

  

rs1042713

Elevated

A

296 (61. 7)

1.41 × 10–1

97(40.4)/102(42.5)/41(17.1)

8.81 × 10–2

5.94 × 10–1

 

Normal

 

763 (57.8)

1.17 (0.95–1.46)

226(34.2)/311(47.1)/123(18.6)

0.77 (0.57–1.04)

0.90 (0.61–1.33)

FCER1B

    

TT/TC/CC

  

rs1441586

Elevated

C

187 (35.4)

3.41 × 10–1

108(40.9)/125(47.3)/31(11.7)

3.82 × 10–1

5.10 × 10–1

 

Normal

 

477 (33.1)

1.11 (0.90–1.37)

317(44.0)/329(45.7)/74(10.3)

1.14 (0.85–1.51)

1.16 (0.74–1.81)

FCER1B

    

TT/TC/CC

  

rs569108

Elevated

C

91 (17.0)

7.26 × 10–1

184(68.7)/77(28.7)/7(2.6)

7.47 × 10–1

8.20 × 10–1

 

Normal

 

235 (16.3)

1.05 (0.80–1.37)

502(69.7)/201(27.9)/17(2.4)

1.05 (0.78–1.42)

1.11 (0.45–2.71)

IL4RA

    

GG/GA/AA

  

rs1805010

Elevated

G

274 (51. 9)

3.22 × 10–1

72(27.3)/130(49.2)/62(23.5)

3.84 × 10–1

4.59 × 10–1

 

Normal

 

708 (49.4)

1.11 (0.91–1.35)

176(24.5)/356(49.7)/185(25.8)

0.87 (0.63–1.19)

0.88 (0.63–1.23)

IL4RA

    

AA/AG/GG

  

rs1801275

Elevated

A

442 (83.4)

6.66 × 10–1

178(67.2)/86(32.5)/1 (0.4)

6.97 × 10–1

3.09 × 10–2

 

Normal

 

1189 (82.6)

1.06 (0.81–1.38)

493(68.5)/203(28.2)/24(3.3)

1.06 (0.79–1.43)

0.11 (0.01–0.82)

  1. SNP single-nucleotide polymorphism, CBIgE cord blood IgE, OR odds ratio, CI confidence interval
  2. *P Values for Pearson’s χ2 tests
  3. Dominant model (AA vs AB + BB) and recessive model (AA + AB vs BB), where A is the major allele and B is the minor allele
  4. P Values for logistic analyses