From: Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children
SNP | CBIgE levels | Risk allele | Risk allele frequency, n (%) | P value *OR(95%CI) | Genotype frequency AA/AB/BB n (%) | Dominant† P value‡ OR(95%CI) | Recessive† P value‡ OR(95%CI) |
---|---|---|---|---|---|---|---|
IL13 | CC/CT/TT | ||||||
rs1800925 | Elevated | T | 102 (19.2) | 5.17 × 10–2 | 170(63.9)/90(33.8)/6(2.3) | 2.79 × 10–2 | 9.77 × 10–1 |
Normal | 223 (15.5) | 1.29 (1.00–1.67) | 512(71.2)/191(26.6)/16(2.2) | 1.40 (1.04–1.88) | 1.01 (0.39–2.62) | ||
IL13 | GG/GA/AA | ||||||
rs1295686 | Elevated | A | 204 (38.5) | 2.73 × 10–3 | 97(36.6)/132(49.8)/36(13.6) | 8.71 × 10–3 | 2.18 × 10–2 |
Normal | 451 (31.3) | 1.37 (1.12–1.69) | 331(46.0)/327(45.4)/62(8.6) | 1.47 (1.10–1.97) | 1.67 (1.08–2.58) | ||
IL13 | CC/CT/TT | ||||||
rs20541 | Elevated | T | 203 (38. 5) | 3.57 × 10–3 | 97(36.7)/131(49.6)/36(13.6) | 1.23 × 10–2 | 2.07 × 10–2 |
Normal | 453 (31.5) | 1.36 (1.11–1.68) | 329(45.7)/329(45.7)/62(8.6) | 1.45 (1.08–1.94) | 1.68 (1.08–2.60) | ||
IL4 | TT/TC/CC | ||||||
rs2243250 | Elevated | C | 109 (20.6) | 7.55 × 10–1 | 168(63.4)/85(32.1)/12(4.5) | 7.00 × 10–1 | 9.71 × 10–1 |
Normal | 287 (19.9) | 1.04 (0.81–1.33) | 466(64.7)/221(30.7)/33(4.6) | 1.06 (0.79–1.42) | 0.99 (0.50–1.94) | ||
ADRB2 | AA/AG/GG | ||||||
rs1042713 | Elevated | A | 296 (61. 7) | 1.41 × 10–1 | 97(40.4)/102(42.5)/41(17.1) | 8.81 × 10–2 | 5.94 × 10–1 |
Normal | 763 (57.8) | 1.17 (0.95–1.46) | 226(34.2)/311(47.1)/123(18.6) | 0.77 (0.57–1.04) | 0.90 (0.61–1.33) | ||
FCER1B | TT/TC/CC | ||||||
rs1441586 | Elevated | C | 187 (35.4) | 3.41 × 10–1 | 108(40.9)/125(47.3)/31(11.7) | 3.82 × 10–1 | 5.10 × 10–1 |
Normal | 477 (33.1) | 1.11 (0.90–1.37) | 317(44.0)/329(45.7)/74(10.3) | 1.14 (0.85–1.51) | 1.16 (0.74–1.81) | ||
FCER1B | TT/TC/CC | ||||||
rs569108 | Elevated | C | 91 (17.0) | 7.26 × 10–1 | 184(68.7)/77(28.7)/7(2.6) | 7.47 × 10–1 | 8.20 × 10–1 |
Normal | 235 (16.3) | 1.05 (0.80–1.37) | 502(69.7)/201(27.9)/17(2.4) | 1.05 (0.78–1.42) | 1.11 (0.45–2.71) | ||
IL4RA | GG/GA/AA | ||||||
rs1805010 | Elevated | G | 274 (51. 9) | 3.22 × 10–1 | 72(27.3)/130(49.2)/62(23.5) | 3.84 × 10–1 | 4.59 × 10–1 |
Normal | 708 (49.4) | 1.11 (0.91–1.35) | 176(24.5)/356(49.7)/185(25.8) | 0.87 (0.63–1.19) | 0.88 (0.63–1.23) | ||
IL4RA | AA/AG/GG | ||||||
rs1801275 | Elevated | A | 442 (83.4) | 6.66 × 10–1 | 178(67.2)/86(32.5)/1 (0.4) | 6.97 × 10–1 | 3.09 × 10–2 |
Normal | 1189 (82.6) | 1.06 (0.81–1.38) | 493(68.5)/203(28.2)/24(3.3) | 1.06 (0.79–1.43) | 0.11 (0.01–0.82) |