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Table 1 hIL-4 neutralization by scFv in normal human keratinocytes (expressed as a relative percentage to poly I:C)

From: Transcutaneous penetration of a single-chain variable fragment (scFv) compared to a full-size antibody: potential tool for atopic dermatitis (AD) treatment

Donors

poly I:C

hIL-4 + poly I:C

scFv 10 nM

scFv 100 nM

scFv 200 nM

scFv 400 nM

scFv 600 nM

D1

100

0

− 39

4

26

44

84

D2

100

0

69

84

118

113

127

D3

100

0

3

21

31

46

43

D4

100

0

− 7

33

28

58

64

Average (%)

100

0

7

36

51

65

80

Standard deviation (%)

0

0

45

35

45

32

36

  1. hIL-4 human interleukin 4, poly I:C polyinosinic-polycytidylic acid, scFv single chain variable fragment, nM nanomolar