Fig. 1

Path analyses assessing DNAm mediation effect on the association of BMI trajectory and asthma incidence. a Effects of BMI-trajectories on methylation of CpGs, controlled for secondhand smoking status at 1, 2 and 4 years. b Effects of CpGs on the incidence of asthma, controlled for BMI trajectories, socio-economic status (SES), active smoking status at 18 years, pubertal events (age at onset of voice deepening in males and age at onset of menarche in females). c Direct effects of BMI trajectories on asthma acquisition