Table 1 Ursodiol desensitization using a 12-step, 2-dilution protocol
From: Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
Step | Concentration (mg/mL) | Time (hr:min) | Route of administration | Volume given per step (mL) | Dose given per step (mg) | Cumulative dose (mg) |
|---|---|---|---|---|---|---|
1 | 5 | 00:00 | Oral | 0.05 | 0.25 | 0.25 |
2 | 5 | 00:45 | Oral | 0.1 | 0.5 | 0.75 |
3 | 5 | 01:30 | Oral | 0.2 | 1 | 1.75 |
4 | 5 | 02:15 | Oral | 0.4 | 2 | 2.75 |
5 | 5 | 03:00 | Oral | 0.8 | 4 | 6.75 |
6 | 5 | 03:45 | Oral | 1.25 | 6.25 | 13 |
7 | 5 | 04:30 | Oral | 2.5 | 12.5 | 25.5 |
8 | 20 | 05:15 | Oral | 1.25 | 25 | 30.5 |
9 | 20 | 06:00 | Oral | 2.5 | 50 | 80.5 |
10 | 20 | 06:45 | Oral | 3.75 | 75 | 155.5 |
11 | 20 | 07:30 | Oral | 7.5 | 150 | 305.5 |
12 | 20 | 08:15 | Oral | 10 | 200 | 505.5 |