Table 3 Top 20 genes differentially expressed in ileal mucosa ranked by absolute log2 fold change (logFC) in asthma vs controls. FDR—false-discovery ratio (Benjamini-Hochberg)
logFC | pFDR | Gene | Gene name and function |
|---|---|---|---|
3.01 | 0.015 | FCGBP | Fc Fragment Of IgG Binding Protein—binds IgG Fc and MUC2 |
2.78 | 0.015 | MUC2 | Mucin 2, Oligomeric Mucus/Gel-Forming—forms mucus layer protecting the intestinal (and airway) epithelium |
2.73 | 0.024 | DEFA1B | Defensin Alpha 1B—antimicrobial peptide |
2.61 | 0.012 | OLFM4 | Olfactomedin 4—intestinal stem cell marker, also secreted by neutrophils during the formation of extracellular traps (NETs) |
2.61 | 0.013 | C1QB | Complement C1q B Chain—the complement bridges innate and adaptive immunity |
2.48 | 0.021 | ITLN1 | Intelectin 1—binds bacterial glycans; adipokine (also known as omentin) |
2.46 | 0.040 | REG4 | Regenerating Family Member 4—lectin-like protein binding manno-oligosaccharides |
2.43 | 0.023 | LYZ | Lysozyme—cleaves bacterial peptidoglycan |
2.39 | 0.018 | PLA2G2A | Phospholipase A2 Group IIA—phospholipase degrading bacterial membrane phospholipids; promotes Paneth cell development |
2.36 | 0.017 | DEFA6 | Defensin Alpha 6—antimicrobial peptide |
2.34 | 0.029 | LOC100134294 | Probe ILMN_3238960—unknown function; upregulated in ulcerative colitis |
2.29 | 0.013 | M160 | CD163 Molecule Like—belongs to cysteine-rich scavenger receptors; may characterize a subset of CD163+colonic CD14+cells |
2.28 | 0.021 | GCG | Glucagon—the transcript encodes glucagon and three other enterohormones, including GLP-2 that stimulates crypt proliferation and gut barrier function |
2.22 | 0.020 | CEACAM5 | CEA Cell Adhesion Molecule 5—cell adhesion molecule; may be elevated in various cancers |
2.20 | 0.017 | SST | Somatostatin—peptide hormone best known for inhibiting the pituitary; also interacts with enterohormones |
2.20 | 0.007 | PDGFRA | Platelet Derived Growth Factor Receptor Alpha; its activity associates with eosinophilia; PDGFRA rearrangement may cause chronic eosinophilic leukemia |
2.19 | 0.017 | FCGBP | Fc Fragment Of IgG Binding Protein (another probe) |
2.17 | 0.020 | CD24 | CD24 Molecule—a peptide binding lectins; expressed by B-cells and granulocytes |
2.17 | 0.038 | HLA-DQA1 | Major Histocompatibility Complex, Class II, DQ Alpha 1—presents antigens; its variants associate with autoimmunity against infliximab in inflammatory bowel diseases |
2.13 | 0.043 | ITLN2 | Intelectin 2—may bind bacterial polysaccharides |