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Table 4 Top 10 transcripts underexpressed in ileal mucosa ranked by increasing absolute log2 fold change (logFC) in asthma vs controls. FDR—false-discovery ratio (Benjamini-Hochberg)

From: Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells

logFC

Average expression

pFDR

Gene

Gene name and function

− 1.93

6.94

0.028

LOC440525

Probe ILMN_1662409—unknown function; increased expression in the intestine after congenital heart defect surgery

− 1.92

7.86

0.017

LOC731789

Probe ILMN_3233239—unknown function; related to rs11015207 that associates with maximal oxygen uptake response after training

− 1.85

7.91

0.009

PDE4A

Phosphodiesterase 4A—regulates cellular cyclic adenosine monophosphate (cAMP); related to asthma; asthma drug target

− 1.84

9.00

0.017

LOC100129201

Probe ILMN_3263918—unknown function; might be hypertension-related

− 1.84

7.31

0.036

PCK1

Phosphoenolpyruvate Carboxykinase 1—controls gluconeogenesis; regulates the citric acid cycle

− 1.78

7.67

0.016

TAF13

TATA-Box Binding Protein Associated Factor 13—involved in initiation of transcription by RNA polymerase II; its mutations associate with schizophrenia

− 1.76

6.70

0.027

LOC100130422

Probe ILMN_3242709—function unknown

− 1.74

8.55

0.033

HINT3

Histidine Triad Nucleotide Binding Protein 3—may act on alpha-phosphate of ribonucleotides

− 1.74

7.13

0.017

KREMEN2

Kringle Containing Transmembrane Protein 2—by enhancing endocytosis of LRP5 and LRP6 inhibits signalling through Wnt/β-catenin pathway

− 1.71

7.90

0.017

TAF13

TATA-Box Binding Protein Associated Factor 13