Skip to main content

Table 2 Characteristics of included studies (part 2)

From: Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis

Study Effect size (95% CI) Adjusted for
Shalom et al. [17] 2020 Celiac disease: aOR = 1.609 (1.42–1.82) Age, sex, smoking status and primary care visits
Narla et al. [20] 2018 32 specific autoimmune diseases: adult (aOR 1.45 1.32–1.58); children (aOR 2.08 1.73–2.5) Age, sex, race/ethnicity, and insurance status
Egeberg et al. [11] 2017 CD: aOR = 1.65 (1.20–2.26); UC: aOR = 1.85 (1.49–2.29) Age, sex, socioeconomic status, and number of dermatologist visits
Andersen et al. [12] 2016 22 specific autoimmune diseases: overall effect not available Age, sex, smoking, socioeconomic status, and number of dermatologist visits
Radtke et al. [10] 2016 CD: OR = 1.71 (1.54–1.91); UC: OR = 1.66 (1.50–1.84); AA: OR = 3.30 (2.95–3.70); vitiligo: OR = 2.60 (2.26–3.00) NA
Augustin et al. [14] 2015 CD: OR = 1.33 (0.87–2.04); UC: OR = 1.75 (1.10–2.79); AA: OR = 2.34 (1.77–3.08); vitiligo: OR = 3.26 (2.51–4.22) NA
Wu et al. [18] 2014 T1DM: aOR = 1.00 (0.90–1.13); PA: aOR = 0.54 (0.20–1.41); RA: aOR = 0.89 (0.74–1.06); SLE: aOR = 1.94 (1.48–2.54); vitiligo: aOR = 1.08 (0.76–1.53); ATD: aOR = 0.93 (0.76–1.14) Age, gender, number of healthcare visits, presence of allergic rhinitis, asthma and the autoimmune disorders listed in this table
Soh et al. [16] 2020 CD: aRR = 2.02 (1.12–3.67); UC: aRR = 1.51 (1.08–2.10) Age, sex, residence, smoking history, alcohol consumption, regular exercise, income, body mass index, diabetes, hypertension, and dyslipidemia
Wei et al. [15] 2020 AA: aRR = 6.00 (5.04–7.14)  
Krishna et al. [9] 2019 CD: aRR = 1.33 (0.87–2.04); UC: aRR = 1.75 (1.10–2.79); AA: aRR = 2.34 (1.77–3.08); vitiligo: aRR = 1.67 (1.50–1.87); Sjogrens syndrome: aRR = 1.52 (1.22–1.88); RA: aRR = 1.31 (1.22–1.41); PA: aRR = 1.23 (1.11–1.35); MG: aRR = 1.04 (0.76–1.41); celiac disease: aRR = 1.37 (1.24–1.52); ATD: aRR = 1.14 (1.00–1.30); multiple sclerosis: aRR = 1.15 (0.96–1.37); SLE: aRR = 2.40 (1.98–2.91) Age, sex, socio-economic status, smoking status, BMI and ethnicity
Drucker et al. [21] 2017 AA: aRR = 1.80 (1.18–2.76); vitiligo: aRR = 2.14 (2.29–3.54) Age, BMI, alcohol intake, physical activity, cigarette smoking status and history of postmenopausal hormone replacement use
Schmitt et al. [13] 2016 CD: aRR = 1.34 (1.11–1.61); UC: aRR = 1.25 (1.03–1.53); RA: aRR = 1.72 (1.12–2.37); T1DM: aRR = 0.72 (0.53–0.998) Age, sex, socioeconomic status, access to health care and health care utilization behavior
Lai et al. [22] 2015 RA: aRR = 1.41 (0.98–2.02) Age, sex, urbanization level, income and diabetes mellitus
Wei et al. [19] 2014 SLE: aRR = 2.92 (1.85–4.60) Sex, age, urbanization, and mutual five allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis and urticaria)
  1. AA alopecia areate, CD Crohn’s disease, RA rheumatoid arthritis, SLE systematic lupus erythematosus, UC ulcerative colitis, aOR adjusted odds ratio, CI confidence interval, aRR adjusted relative risk