Table 1 Characteristics of our patient and of published cases with isotretinoin therapy and relevant food allergy
Patients | Relevant allergy history | Prick test isotre-tinoin | Oral provocation isotretinoin | Tolerance of isotretinoin therapy | Total serum IgE | IgE to soybean allergens | Prick soy-bean | IgE to peanut allergens | Prick peanut | References |
|---|---|---|---|---|---|---|---|---|---|---|
n = 2 | Anaphylaxis not specified (peanut) |  | No reaction | Tolerated |  |  |  |  |  | Walsh et al. [15] |
n = 6 | Severe anaphylaxis (peanut) | Neg | No reaction | Tolerated |  |  | + |  | + | Spierings et al. [21] |
n = 1 | Allergy to cashew nut |  |  | Facial angioedema after 1st dose, throat swelling on day 3 |  | Gly m 4 1.38 kU/l |  |  |  | Alden et al. [7] |
n = 4 | Allergy to peanut |  |  | Tolerated |  | Gly m 4 neg Gly m 5 neg Gly m 6 neg | − |  |  | Alden et al. [7] |
n = 1 | Peanut elimination since childhood due to IgE detection | Neg | No reaction | Tolerated | 4229 kU/l | Soybean extract 0.39 kU/l | + | Peanut extract 35.7 kU/l Ara h 2 7.97 kU/l Ara h 8 3.72 kU/l | + | Alvarez-Arango et al. [20] |
n = 1 | Urticaria, facial angioedema, dyspnoea (peanut) | Neg | no reaction | Tolerated | 959 kU/l | Soybean extract neg |  | Peanut extract 3.93 kU/l Ara h 2 0.71 kU/l | + | Pierret et al. [16] |
n = 1 | Nausea, throat tightness (peanut) | Neg | No reaction | Tolerated | 817 kU/l |  |  | Ara h 2 4.12 kU/l Ara h 8 9.74 kU/l Ara h 9 neg | + | Hulstaert et al. [17] |
n = 1 | Anaphylaxis to peanut | Neg | No reaction | Tolerated |  |  |  |  | + | Paugam et al. [18] |
n = 1 | Facial angio-edema, pruritus, dyspnoea (peanut) | Neg | No reaction | Tolerated | 915 kU/l | Gly m 4 neg Gly m 5 6.82 kU/l Gly m 6 12.7 kU/l | + | Ara h 2 > 100 Ara h 8 neg Ara h 9 neg | + | Denorme et al. [13] |
n = 11 | Allergy to peanut (n = 10), to cashew (n = 1) |  |  | Tolerated |  | Gly m 4 neg Gly m 5 neg Gly m 6 neg | − |  |  | Alden et al. [6] |
n = 7 | Allergy to peanut or tree nut | Neg | No reaction | Tolerated |  |  |  |  |  | Ostlere et al. [2] |
n = 1 | Allergy to peanut |  |  | Tolerated |  | Soybean extract neg | − |  | + | Humphrey et al. [19] |
n = 1 | Oral allergy syndrome to hazelnut, dyspnoea after sesame | Neg | No reaction | Exercise-induced anaphylaxis (°2), however tolerance in absence of cofactors | 2903 kU/l | Gly m 4 95.0 kU/l Gly m 5 neg Gly m 6 neg | + | Ara h 2 neg Ara h 8 > 100 Ara h 9 10.8 | + | Present case |