Table 1 Laboratory investigations of patients at baseline and during an URTI or flu-like illness, along with corresponding symptom survey results

Demographics

 Age at baseline (years)

35

69

43

67

 Sex

Male

Female

Female

Female

Baseline

 Ferritin (15–247 μg/L)

103

79

7

10

 CRP (<  4.8 mg/L)

0.4

2.4

<  0.3

2.1

 C4 (0.09–0.50 g/L)

0.03

0.07

0.02

0.07

 C1- INH function (0.70–1.30 U)

0.16

0.25

0.12

0.30

Illness #1

 Ferritin (15–247 μg/L)

121

93

9

49 ↑

 CRP (<  4.8 mg/L)

4.2

3.6

0.3

5.6 ↑

 C4 (0.09–0.50 g/L)

0.05

0.08

0.04

0.12 ↑

 C1-INH function (0.70–1.30 U)

0.22

0.28

0.14

0.37

 Symptoms experienced

Fever, chills, sore throat

Sore throat, rhinorrhea, nasal congestion

Fever, muscle aches, congestion, fatigue

Cough, sore throat, rhinorrhea, congestion

 Duration of illness (days)

2

2

7

18

 Severity of illness (1–5)

3

1

2

2

 HAE attack within preceding 48 h (Y/N)

N

N

N

N

Illness #2

 Ferritin (15–247 μg/L)

123

40 ↑

 CRP (<  4.8 mg/L)

13.9 ↑

2.5

 C4 (0.09–0.50 g/L)

0.10 ↑

0.13 ↑

 C1-INH function (0.70–1.30 U)

0.24

0.34

 Symptoms experienced

Cough, rhinorrhea

Cough, sore throat, rhinorrhea, congestion

 Duration of illness (days)

Not recorded

16

 Severity of illness (1–5)

1

2

 HAE attack within preceding 48 h (Y/N)

N

N