Fig. 1
The clinical progress of Histobulin™ therapy in CSU. a Clinical progress. b Five steps of clinical progress in Histobulin™ therapy: initial improvement (initial improvement), reduction in medication frequency per week (medication reduction), cessation of medication (medication free) without the symptoms and signs of CSU, free of symptoms without medication (symptom free) and persistence of symptom-free status for more than 4 weeks without any medication or treatment (remission)