From: Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
Class | Central nervous system | Cardiovascular | Toxic high dose |
---|---|---|---|
First-generation | agitation, confusion, dystonia, dyskinesia, hallucinations, headache impairment in coordination, learning, memory, psychomotor and sensorimotor functions, and sedation | dose-dependent sinus tachycardia, reflex tachycardia, atrial refractory period prolongation and supraventricular arrhythmias | severe CNS and cardiac side effects, may lead to death unless treated |
Second-generation | variable (such as sedation with cetirizine) Minimal or no side effects | no side effects | no severe side effects or deaths reported |