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Table 1 Characteristics of the included studies

From: Cumulative evidence for association of rhinitis and depression

Study

Publication year

Study location

Study design

Sample size

Participants

Ascertainment of rhinitis

Type of rhinitis

Diagnosis of rhinitis

Ascertainment of depression

Depression diagnostic criteria

Outcomes

Confounding factors

Data source

Zhou

2017

United States

Cross-sectional

19.1 ± 1.1 million

Adults

Survey participants self-reported

AR

NA

Survey self-reported

NA

1.32 (1.12–1.54)

Region, sex, race, income, education, and age

2014 (NHIS)

Yamamoto-Hanada

2019

Japan

Cross-sectional

86,085

Pregnant women

Self-reported

Rhinitis

NA

Self-reported

K-6 ≥ 5

1.2 (1.17–1.24)

NA

NA

Roxbury

2019

United States

Cross-sectional

4320

Adults

Self-reported

Rhinitis/AR/NAR

NA

Self-reported

PHQ-9 ≥ 10

1.42 (1.03–1.95)/0.9 (0.68–1.18)/1.99(1.34–2.96)

Age, gender, race, obesity comorbid medical conditions, including self-reported history of asthma, coronary artery disease, heart attack, stroke, thyroid disease, emphysema, chronic bronchitis, and trouble seeing; and self-rated general health condition (excellent, very good, good, fair, or poor)

2005–2006 (NHANES)

Kim

2016

Korea

Cross-sectional study

11,154

> 19 y

Self-reported

AR

NA

Self-reported

EuroQol 5-dimension (EQ-5D)

2.585 (1.519–4.398)/severe 1.49 (0.894–2.481)

1.254 (0.897–1.752)

Age, sex, BMI, smoking status, alcohol use status, exercise status, region of residence, income, education, marital status, asthma, and atopic dermatitis

KNHANES, 2011–2012

Nanda

2016

United States

Prospective cohort

546

4–7 y

Diagnosed

AR

1 aeroallergen SPT positive+

Diagnosed

BASC-2

3.2 (1.7–6.5)

Gender, parental asthma, maternal education, BMI, and sleep disturbance

2001–2003, CCAAPS

Chen

2013

Taiwan

Prospective cohort study

1673

12-15y

Diagnosed

AR

ICD-9-CM

Diagnosed

ICD-9-CM

1.59 (1.02–2.50)

Residence location and comorbid allergic diseases

1996–2000, NHIRD

Bedolla-Barajas

2017

Mexico

Cross-sectional study

241

≥ 18 and ≤ 50

Diagnosed

AR/NAR

 

Diagnosed

BDI-II > 13

2.5 (1.24–4.9)/3.3 (1.28–8.25)

Sex

2012–2013

Valero

2015

Spain

Cross-sectional study

670

> 18 y

Self-reported

Rhinitis

NA

Self-reported

HAD

17.6% vs. 4.76%

NA

NA

Wei

2016

Taiwan

Cohort

5075/44729

10–17 y

Diagnosed

Rhinitis

ICD-9-CM

Diagnosed

ICD-9-CM

1.8 [1.29–2.50]

Demographic data

1995–2000, NHIRD

Audino

2014

Italy

Cross-sectional study

1283

10–13 y

Self-reported

Rhinitis

NA

Diagnosed

TAD > 115

17.7% vs. 11.2%

NA

Palermo, Italy

Derebery

2008

United States

Cohort

7024

> 18 y

Self-reported

Rhinitis

NA

Self-reported

NA

17.2% (3831) vs. 8.3% (3193)

NA

2004 NFO

Tas

2019

Turkey

Cross-sectional

101/74

> 18 y

Diagnosed

AR

Endoscopic nasal examination

Self-reported

TEMPS-A

23.8% (24/101) vs. 10.8% (8/74)

NA

2017–2018

Shin

2018

Korea

Cross-sectional study

15,441

> 19 y

Self-reported

AR

NA

Self-reported

HRQoL

1.72 (1.08–2.73)

Age, gender, educational level, marital status, household income, occupation, residential area, smoking status, alcohol consumption, exercise status, sleep duration, and obesity; comorbidities, such as hypertension, diabetes, stroke, ischemic heart disease, arthritis, asthma, atopic dermatitis, thyroid disease, liver cirrhosis, chronic renal failure, and depression; activity limitations; subjective health; and total cholesterol and triglyceride levels

2013–2015 KNHANES

Seo

2012

Korea

Cross-sectional

76,937

Adolescents

Self-reported

AR

NA

Self-reported

NA

1.14 (1.08–1.20)

NA

2009 Korean Youth’s Risk Behavior Web-based Study

  1. AR allergic rhinitis, BASC-2 Behavior Assessment System for Children, Second Edition, BDI-II Beck Depression Inventory-II, CCAAPS Cincinnati Childhood Allergy and Air Pollution Study, CI confidence interval, EPOS European Position Paper on Rhinosinusitis and Nasal Polyps, HADS Hospital Anxiety and Depression score, ICD-9-CM International Classification of Disease, 9th Revision, Clinical Modification, K-6 Kessler’s K-6 Non-Specific Psychological Distress Scale, KNHIS-NSC National Sample Cohort of the Korea National Health Insurance Service, TAD testing for depression and anxiety characteristics using the Depression and Anxiety in Youth Scale, KNHANES Korean National Health and Nutrition Examination Survey, NA not applicable because only 1 study, NAR nonallergic rhinitis, NFO National Family Opinion, NHANES National Health and Nutrition Examination Survey, NHIRD National Health Insurance Research Database, NHIS National Health Interview Survey, NHIRD National Health Insurance Research Database, NPHS National Population Health Survey, OR odds ratio, QOL quality of life, TEMPS-A Temperament Evaluation of Memphis, Pisa, Paris, France, San Diego Auto-questionnaire