From: Malignancy and immune disorders in patients with hereditary angioedema
Patient number | Age at time of study | Sex | Age of HAE diagnosis | Details of HAE diagnosis | Type of malignancy | Age of malignancy diagnosis | Extent of malignancy and treatment |
---|---|---|---|---|---|---|---|
Patient 1 | 57 | F | 41 | Multiple family members with HAE on paternal side | Breast | 54 | Invasive ductal carcinoma − ER/PR + , HER2 equivocal, treated with surgery and post-menopausal state |
Patient 2 | 58 | M | 12 | 8 family members with HAE | Melanoma | 56 | Stage 3 with unknown primary, treated with surgery and chemotherapy |
Patient 3 | 70 | F | 66 | Sister, father and daughter with HAE | Pancreatic | 70 | Metastatic, passed away shortly after diagnosis |
Patient 4 | 46 | F | 42 | Mother and maternal aunt with HAE | Cervical dysplasia (ASC-H, prior HSIL) | Early 40 s, prior to HAE diagnosis | Localized, treated with Hysterectomy. Currently being investigated for bladder cancer |
Patient 5 | 58 | F | 56 | Brother and nephew with HAE | Breast | 50 | Treated with mastectomy and tamoxifen for five years |
Patient 6 | 74 | F | 73 | Mutation in SERPING1, suspected family history (currently being investigated) | Renal | 62 | Metastatic, treated with nephrectomy, immunotherapy, and localized radiation |