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Table 1 Details of HAE patients with Malignancy Diagnosis

From: Malignancy and immune disorders in patients with hereditary angioedema

Patient number

Age at time of study

Sex

Age of HAE diagnosis

Details of HAE diagnosis

Type of malignancy

Age of malignancy diagnosis

Extent of malignancy and treatment

Patient 1

57

F

41

Multiple family members with HAE on paternal side

Breast

54

Invasive ductal carcinoma − ER/PR + , HER2 equivocal, treated with surgery and post-menopausal state

Patient 2

58

M

12

8 family members with HAE

Melanoma

56

Stage 3 with unknown primary, treated with surgery and chemotherapy

Patient 3

70

F

66

Sister, father and daughter with HAE

Pancreatic

70

Metastatic, passed away shortly after diagnosis

Patient 4

46

F

42

Mother and maternal aunt with HAE

Cervical dysplasia (ASC-H, prior HSIL)

Early 40 s, prior to HAE diagnosis

Localized, treated with Hysterectomy. Currently being investigated for bladder cancer

Patient 5

58

F

56

Brother and nephew with HAE

Breast

50

Treated with mastectomy and tamoxifen for five years

Patient 6

74

F

73

Mutation in SERPING1, suspected family history (currently being investigated)

Renal

62

Metastatic, treated with nephrectomy, immunotherapy, and localized radiation

  1. ER estrogen receptor, PR progesterone receptor, HER2 Herceptin receptor, ASC-H atypical squamous cells, HSIL high-grade squamous intraepithelial lesion