Table 4 Correlation of various genetic variants with serum IL-4 levels in Atopy patients
From: Atopy in Kashmir-validation from a case control study with respect to IgE and Interleukin genes
Overall genotype | Cases | OR (95%CI) | P value | ||
|---|---|---|---|---|---|
Number | U | D | |||
(n) | n (%) | n (%) | |||
n = 528 | 120 (22.7) | 408 (77.3) | |||
IL-4 RA (A148G) |  |  |  | 2.0 (1.1–3.7) | 0.01 |
 AA | 108 (20.4) | 15 | 93 | ||
 AG + GG | 420 (79.6) | 105 | 315 | ||
IL-4RA (A1902G) |  |  |  | 1.5 (0.8–2.5) | 0.17 |
 AA | 102 (19.3) | 18 | 84 | ||
 AG + GG | 426 (70.7) | 102 | 324 | ||
IL-4 70 bp VNTR |  |  |  | 0.8 (0.5–1.3) | 0.4 |
 2 repeats | 93 (17.6) | 24 | 69 | ||
 2/3 repeats | 435 (72.4) | 96 | 339 | ||
IL-13 (C1055T) |  |  |  | 0.8 (0.5–1.2) | 0.4 |
 CC | 207 (39.2) | 51 | 156 | ||
 CT + TT | 321 (60.8) | 69 | 252 | ||
IL-13 (A1512C) |  |  |  | 0.5 (0.3–0.8) | 0.005 |
 AA | 99 (18.7) |  |  | ||
 AC + CC | 429 (71.3) | 33 | 66 | ||
STAT-6 (G2964A) |  |  |  | 0.6 (0.4–0.95) | 0.03 |
 GG | 156 (29.5) | 87 | 342 | ||
 GA + AA | 372 (70.5) | 75 | 297 | ||