From: Atopy in Kashmir-validation from a case control study with respect to IgE and Interleukin genes
Variables | Cases | Controls | OR (95%CI) | P value | ||||
---|---|---|---|---|---|---|---|---|
Number (n) | Un (%) | D | Number | Un (%) | Dn (%) | |||
n (%) | (n) | |||||||
n = 528 | 00 (00.00) | 528 (100.0) | n = 610 | 215 (35.3) | 395 (64.7) | – |  < 0.0001 | |
Age |  |  |  |  |  |  | – |  |
 < 40 | 414 (78.4) | 00 | 414 | 459 (75.0) | 158 | 301 |  < 0.0001 | |
 > 40 | 114 (21.6) | 00 | 114 | 151 (25.0) | 57 | 94 |  < 0.0001 | |
Gender |  |  |  |  |  |  | – |  |
 Male | 210 (39.8) | 00 | 310 | 255 (41.8) | 83 | 172 |  < 0.0001 | |
 Female | 318 (60.2) | 00 | 318 | 355 (58.2) | 132 | 223 |  < 0.0001 | |
Dwelling |  |  |  |  |  |  | – |  |
 Urban | 240 (45.5) | 00 | 240 | 281 (46.1) | 108 | 173 |  < 0.0001 | |
 Rural | 288 (54.5) | 00 | 288 | 329 (44.9) | 107 | 222 |  < 0.0001 | |
Smoking status |  |  |  |  |  |  | – |  |
 Smokers | 63 (12.0) | 00 | 63 | 38 (6.2) | 12 | 26 |  < 0.0001 | |
 Non-smokers | 165 (31.2) | 00 | 165 | 345 (56.5) | 80 | 147 |  < 0.0001 | |
 Passive smokers | 300 (56.8) | 00 | 300 | 227 (37.3) | 123 | 222 |  < 0.0001 | |
IgE Levels: |  |  |  |  |  |  | – |  |
 Normal | 03 (0.6) | 00 | 3 | 487 (79.8) | 175 | 312 |  < 0.0001 | |
 Elevated | 525 (99.4) | 00 | 525 | 123 (20.2) | 40 | 83 |  < 0.0001 | |
Eosinophil count |  |  |  |  |  |  | – |  |
 Normal | 297 (56.3) | 00 | 297 | 519 (85.1) | 183 | 336 |  < 0.0001 | |
 Elevated | 231 (43.7) | 00 | 231 | 91 (14.9) | 32 | 59 |  < 0.0001 | |
Vitamin D levels (ng/ml) |  |  |  |  |  |  | – |  |
 Deficient (< 20) | 345 (65.3) | 00 | 345 | 503 (82.4) | 173 | 330 |  < 0.0001 | |
 Insufficient (20–30) | 111 (21.0) | 00 | 111 | 49 (8.0) | 18 | 31 |  < 0.0001 | |
 Sufficient (31–100) | 72 (13.7) | 00 | 72 | 58 (9.6) | 24 | 34 |  < 0.0001 | |
ESR |  |  |  |  |  |  | – | 0.3 |
 Normal | 414 (78.4) | 00 | 414 | |||||
 Elevated | 114 (21.6) | 00 | 114 | |||||
PFT |  |  |  |  |  |  | – | 0.6 |
 Normal | 324 (61.4) | 00 | 324 | |||||
 Abnormal | 204 (38.6) | 00 | 204 | |||||
SPT |  |  |  |  |  |  | – |  |
 HDM | 72 (13.6) | 00 | 72 | |||||
 Pollens | 39 (7.3) | 00 | 39 | |||||
 HDM/pollens | 114 (21.6) | 00 | 114 | |||||
 HDM/pollens/fungi /AE | 66 (12.5) | 00 | 66 | |||||
 HDM/pollens/few foods/AE | 225 (42.6) | 00 | 225 | |||||
 Negative | 12 (2.2) | 00 | 12 | |||||
Socio economic status |  |  |  |  |  |  | – | 0.5 |
 Good | 150 (28.4) | 00 | 150 | 0.4 | ||||
 Average | 336 (63.6) | 00 | 336 |  | ||||
 Poor | 42 (8.0) | 00 | 42 |  | ||||
Seasonal/year round |  |  |  |  |  |  | – | 0.4 |
 Year round | 387 (73.3) | 00 | 387 | |||||
 Seasonal | 141 (26.7) | 00 | 141 | |||||
Peak time |  |  |  |  |  |  | – | 0.7 |
 Morning | 255 (48.2) | 00 | 255 | 0.1 | ||||
 Evening | 249 (47.1) | 00 | 249 |  | ||||
 Both | 24 (4.5) | 00 | 24 |  | ||||
Family history |  |  |  |  |  |  | – | 0.5 |
 Yes | 393 (74.5) | 00 | 393 | |||||
 No | 135 (25.5) | 00 | 135 | |||||
Triggers |  |  |  |  |  |  | – | – |
 Dust | 174 (32.9) | 00 | 174 | |||||
 Dust/irritant | 210 (39.7) | 00 | 210 | |||||
 Temperature | 12 (2.3) | 00 | 12 | |||||
 Irritants | 132 (25.0) | 00 | 132 | |||||
Co-morbidity |  |  |  |  |  |  | – | – |
 Diabetes | 24 (4.5) | 00 | 24 | |||||
 Hypertension | 27 (5.1) | 00 | 27 | |||||
 Diabetes/hypertension/obesity | 16 (2.7) | 00 | 16 | |||||
 Hypothyroidism | 51 (9.6) | 00 | 51 | |||||
 PCOD | 21 (3.9) | 00 | 21 | |||||
 Nil | 389 (73.6) | 00 | 389 | |||||
Collateral diseases |  |  |  |  |  |  | – | – |
 Drug allergy | 60 (11.5) | 00 | 60 | |||||
 Migraine | 120 (22.7) | 00 | 120 | |||||
 Food allergy | 90 (17.0) | 00 | 90 | |||||
 Migraine/food allergy | 09 (1.7) | 00 | 9 | |||||
 Migraine/drug allergy | 06 (1.1) | 00 | 6 | |||||
 Nil | 243 (46.0) | 0 | 243 | |||||
Diagnosis |  |  |  |  |  |  | – | – |
 AR/BA | 210 (39.7) | 00 | 210 | |||||
 AR/AD | 57 (10.8) | 00 | 57 | |||||
 AR/CU | 36 (6.8) | 00 | 36 | |||||
 AR/BA/AD | 120 (22.7) | 00 | 120 | |||||
 AR/BA/CU | 75 (14.2) | 00 | 75 | |||||
 AR/BA/conjunctivitis | 12 (2.3) | 00 | 12 | |||||
 BA/CU | 18 (3.4) | 00 | 18 |