Table 1 Immunologic work-up of the DOCK2 deficient-patient
Parameters | 19 months old | 26 months old | Normal ranges |
|---|---|---|---|
WBC × 103 (cell/µL) | 25.5 | 6.7 | 5.5–15.5 |
Lymphocytes (cell/µL ) | 11,700 | 1641 | 3873–6141 |
Hemmoglobin (g/dL) | 9.5 | 9.8 | 10.9–15 |
CD3 + T cells (cell/µL) | 6470 | 1709 | 1578–3707 |
CD4 + T cells (cell/µL) | 322 | 34 | 870–2144 |
CD8 + T cells (cell/µL) | 2697 | 581 | 472–1107 |
CD4/CD8 Ratio | 0.16 | 0.058 | 0.9–3.7 |
CD19 + (cell/µL) | 2597 | 1900 | 434–1274 |
CD20 + (cell/µL) | ND | 1900 | 124–1665 |
CD16 + (cell/µL) | 1111 | 1178 | 78–703 |
CD56 + (cell/µL) | 1743 | 874 | 45–555 |
CD16 + 56 (cell/µL) | 760 | 380 | 155–565 |
IgG (mg/dL) | ND | 511 | 424–1051 |
IgM (mg/dL) | 79 | 41 | 48–168 |
IgA (mg/dL) | 72 | 85.1 | 14–123 |
IgE (IU/mL) | 471 | 400 | < 100 |
C3 (mg/mL) | 113 | ND | 84–174 |
C4 (mg/mL) | 27 | ND | 12–40 |
CH50 (IU/mL) | > 90 | 116 | 70–150 |
MFI/PMA ox-DHR (%) | 40.2% | ND | > 30% |
HIV 1,2 antigen/ antibody (S/CO) | ND | 0.03 | < 0.9 |
Anti-tetanus antibody (IU/mL) | ND | 0.19 | > 0.1 |
Anti-diphtheria antibody (IU/mL) | ND | 0.03 | > 0.1 |