Fig. 1
From: Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience
Treatment Steps prior and after the initiation of tiotropium. Panel A depicts the number (proportion) of children at each age-specific Step before, and Panel B, the change in therapy after, tiotropium (Tio) initiation, occurring in 1 or more than 1 (full arrow with the number of patients on top) patient. The number of adjunct therapy (Rx) added to a medium (MED) or high dose inhaled corticosteroids (ICS), is listed. Treatment steps were classified in accordance with the Global Initiative for Asthma (GINA); however, in children less than 6 years in whom there is no GINA Step 5, we assumed that those on Step 4, in whom tiotropium was an added adjunct therapy, have moved to Step 5