Dietary exposures and allergy prevention in high-risk infants

Table 1 Exposures and associations with food allergy prevention

Exposure	Does contribute	Does not contribute	Highest level of study evidence	Quality of evidence
Maternal peanut ingestion during pregnancy and breastfeeding	−	+	Observational	B
Probiotics	−	+	RCT	C
Breastfeeding	−	++	Observational	B
Hydrolyzed formula	−	+++	Observational	B
Early allergenic food introduction for infants (peanut at 4–11 months of age; egg at 4–6 months)	+++	−	RCT	A
Vitamin D supplementation	−	+	Observational	B

GRADE Working Group. Quality of Evidence: A (Further research is unlikely to change this recommendation); B (Further research is likely to have an impact on our confidence in this recommendation); C (Further research is very likely to have an important impact on our confidence in this estimate of effect)
Based on scoping review of the literature to date on a scale of: − < + < ++ < +++
RCT Randomized controlled trial
Source: [75] Adapted with permission

ISSN: 1710-1492