Failure of a single day metronidazole desensitization protocol, and success of a modified two-day protocol in an outpatient setting

Table 1 Metronidazole desensitization protocols

Dose	Kurohara et al. [2]	Grendelman et al. [4]	Current modified regimen
1	0.0025 mg	0.0025 mg	0.0025 mg
2	0.025 mg	0.025 mg	0.01 mg
3	0.25 mg	0.25 mg	0.02 mg
4	2.5 mg	2.5 mg	0.025 mg
5	25 mg	5 mg	0.25 mg
6	250 mg	10 mg	2.5 mg
7	500 mg	25 mg	5 mg
8	1000 mg	50 mg	10 mg
9		100 mg	25 mg
10		250 mg	50 mg
11		500 mg	100 mg
12		1000 mg	250 mg

			Day 2: premedication with oral anti-histamine
13			250 mg
14			500 mg

ISSN: 1710-1492