Fig. 2From: Hereditary angioedema due to C1 inhibitor deficiency: real-world experience from the Icatibant Outcome Survey in SpainSeverity of HAE attacks before treatment for patients in IOS with available data on this parameter in a Spain (1215 attacks) and b other countries (4787 attacks). P < 0.0001 severe/very severe attacks for Spain vs other IOS countries. HAE hereditary angioedema, IOS Icatibant Outcome SurveyBack to article page