Fig. 2
Antigen-induced changes in lung function in guinea pigs. a Average maximum (Rmax) bronchoobstructive index (Bi) induced by indirect (ovalbumin antigen) provocation. b The PD200 ratio resulting from direct (histamine) provocation was determined according to the PD200 value observed after antigen challenge divided by the PD200 value determined before challenge. c The average intrinsic baseline Bi obtained before indirect and direct provocation. d Difference in the baseline Bi (Δ baseline Bi) obtained after reinforcement (R) and the last challenge with saline (white bar, control) or antigen (black bar, asthma model). Values correspond to challenge with saline (white square) and antigen (black squares) in guinea pigs. *P < 0.05 compared with the control according to repeated measures ANOVA followed by Dunnett’s test. +P < 0.05 compared with the control (unpaired Student’s t-test). The dotted line in B shows the border between hypo- and hyperresponsiveness